Anti-inflammatory effects of α-humulene and β-caryophyllene on pterygium fibroblasts

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorRegional University of Cariri-
Autor(es): dc.creatorHata Viveiros, Magda Massae-
Autor(es): dc.creatorSilva, Márcia Guimarães-
Autor(es): dc.creatorda Costa, José Galberto Martins-
Autor(es): dc.creatorde Oliveira, Anselmo Gomes-
Autor(es): dc.creatorRubio, Carolina-
Autor(es): dc.creatorPadovani, Carlos Roberto-
Autor(es): dc.creatorRainho, Cláudia Aparecida-
Autor(es): dc.creatorSchellini, Silvana Artioli-
Data de aceite: dc.date.accessioned2025-08-21T16:12:16Z-
Data de disponibilização: dc.date.available2025-08-21T16:12:16Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2021-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.18240/ijo.2022.12.02-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/247999-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/247999-
Descrição: dc.description• AIM: To investigate the anti-inflammatory effects of the sesquiterpenes α-humulene and β-caryophyllene on pterygium fibroblasts. • METHODS: Primary cultures of pterygium fibroblasts were established. Third passage pterygium fibroblasts were exposed to α-humulene and β-caryophyllene separately and together. The cell viability was assessed by 3-(4,5-dimethylthiazolyl-2) -2,5-diphenyltetrazolium bromide (MTT) assay at 12, 24, 48, and 72h after exposure. The levels of the inflammatory cytokines interleukin (IL)-1β, IL-6, IL-8, tumor necrosis factor (TNF)-α and IL-10 in the conditioned culture medium were assessed by enzyme-linked immunosorbent assay (ELISA) at 12, 24 and 48h after exposure. Data were statistically analyzed using Friedman repeated measures analysis of variances on ranks. • RESulTS: The 25 μmol/L β-caryophyllene induced significant decrease in the IL-6 production by pterygium fibroblasts 48h after the exposure (P=0.041). The levels of IL-1β, IL-8, IL-10, and TNF-α were very low and had no statistically significant variations after exposure to α-humulene, β-caryophyllene, or both compounds together. • COnCluSIOn:Theexposureto25μmol/Lofβ-caryophyllene significantly reduce the production of IL-6 by pterygium fibroblasts after 48h. This sesquiterpene may be a potential alternative adjuvant agent for the treatment of pterygium.-
Descrição: dc.descriptionDepartment of Ophthalmology School of Medicine of Botucatu São Paulo State University-UNESP, Sao Paulo-
Descrição: dc.descriptionDepartment of Pathology School of Medicine of Botucatu São Paulo State University-UNESP, Sao Paulo-
Descrição: dc.descriptionDepartment of Biological Chemistry Regional University of Cariri, Ceará-
Descrição: dc.descriptionDepartment of Pharmacology School of Pharmaceutical Sciences São Paulo State University-UNESP, Sao Paulo-
Descrição: dc.descriptionBiological Sciences Institute of Biosciences of Botucatu São Paulo State University-UNESP, Sao Paulo-
Descrição: dc.descriptionDepartment of Biostatistics São Paulo State University-UNESP, Sao Paulo-
Descrição: dc.descriptionDepartment of Ophthalmology School of Medicine of Botucatu São Paulo State University-UNESP, Sao Paulo-
Descrição: dc.descriptionDepartment of Pathology School of Medicine of Botucatu São Paulo State University-UNESP, Sao Paulo-
Descrição: dc.descriptionDepartment of Pharmacology School of Pharmaceutical Sciences São Paulo State University-UNESP, Sao Paulo-
Descrição: dc.descriptionBiological Sciences Institute of Biosciences of Botucatu São Paulo State University-UNESP, Sao Paulo-
Descrição: dc.descriptionDepartment of Biostatistics São Paulo State University-UNESP, Sao Paulo-
Formato: dc.format1903-1907-
Idioma: dc.languageen-
Relação: dc.relationInternational Journal of Ophthalmology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectcytokines-
Palavras-chave: dc.subjectfibroblasts-
Palavras-chave: dc.subjectpterygium-
Palavras-chave: dc.subjectα-humulene-
Palavras-chave: dc.subjectβ-caryophyllene-
Título: dc.titleAnti-inflammatory effects of α-humulene and β-caryophyllene on pterygium fibroblasts-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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