Multiclonal human origin and global expansion of an endemic bacterial pathogen of livestock

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Autor(es): dc.contributorUniversity of Edinburgh-
Autor(es): dc.contributorTechnical University of Denmark-
Autor(es): dc.contributorStatens Serum Institut-
Autor(es): dc.contributorMississippi State University-
Autor(es): dc.contributorMurdoch University-
Autor(es): dc.contributorUniversity of Sydney-
Autor(es): dc.contributorUniversity of Pretoria-
Autor(es): dc.contributorNational Health Laboratory Service-
Autor(es): dc.contributorUniversity of Buenos Aires-CONICET-
Autor(es): dc.contributorOhio State University-
Autor(es): dc.contributorMichigan State University-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversiti Putra Malaysia-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorAnimal & Bioscience Department-
Autor(es): dc.contributorUniversity of Cambridge-
Autor(es): dc.contributorJanssen Immunology-
Autor(es): dc.creatorYebra, Gonzalo-
Autor(es): dc.creatorHarling-Lee, Joshua D.-
Autor(es): dc.creatorLycett, Samantha-
Autor(es): dc.creatorAarestrup, Frank M.-
Autor(es): dc.creatorLarsen, Gunhild-
Autor(es): dc.creatorCavaco, Lina M.-
Autor(es): dc.creatorSeo, Keun Seok-
Autor(es): dc.creatorAbraham, Sam-
Autor(es): dc.creatorNorris, Jacqueline M.-
Autor(es): dc.creatorSchmidt, Tracy-
Autor(es): dc.creatorEhlers, Marthie M.-
Autor(es): dc.creatorSordelli, Daniel O.-
Autor(es): dc.creatorBuzzola, Fernanda R.-
Autor(es): dc.creatorGebreyes, Wondwossen A.-
Autor(es): dc.creatorGonçalves, Juliano L.-
Autor(es): dc.creatordos Santos, Marcos V.-
Autor(es): dc.creatorZakaria, Zunita-
Autor(es): dc.creatorRall, Vera L.M.-
Autor(es): dc.creatorKeane, Orla M.-
Autor(es): dc.creatorNiedziela, Dagmara A.-
Autor(es): dc.creatorPaterson, Gavin K.-
Autor(es): dc.creatorHolmes, Mark A.-
Autor(es): dc.creatorFreeman, Tom C.-
Autor(es): dc.creatorFitzgerald, J. Ross-
Data de aceite: dc.date.accessioned2025-08-21T20:56:55Z-
Data de disponibilização: dc.date.available2025-08-21T20:56:55Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2022-12-12-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1073/pnas.2211217119-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/247996-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/247996-
Descrição: dc.descriptionMost new pathogens of humans and animals arise via switching events from distinct host species. However, our understanding of the evolutionary and ecological drivers of successful host adaptation, expansion, and dissemination are limited. Staphylococcus aureus is a major bacterial pathogen of humans and a leading cause of mastitis in dairy cows worldwide. Here we trace the evolutionary history of bovine S. aureus using a global dataset of 10,254 S. aureus genomes including 1,896 bovine isolates from 32 countries in 6 continents. We identified 7 major contemporary endemic clones of S. aureus causing bovine mastitis around the world and traced them back to 4 independent host-jump events from humans that occurred up to 2,500 y ago. Individual clones emerged and underwent clonal expansion from the mid-19th to late 20th century coinciding with the commercialization and industrialization of dairy farming, and older lineages have become globally distributed via established cattle trade links. Importantly, we identified lineage-dependent differences in the frequency of host transmission events between humans and cows in both directions revealing high risk clones threatening veterinary and human health. Finally, pangenome network analysis revealed that some bovine S. aureus lineages contained distinct sets of bovine-associated genes, consistent with multiple trajectories to host adaptation via gene acquisition. Taken together, we have dissected the evolutionary history of a major endemic pathogen of livestock providing a comprehensive temporal, geographic, and gene-level perspective of its remarkable success.-
Descrição: dc.descriptionThe Roslin Institute University of Edinburgh-
Descrição: dc.descriptionThe National Food Institute Technical University of Denmark-
Descrição: dc.descriptionDepartment for Bacteria Parasites and Fungi Reference Laboratory for Antimicrobial Resistance Statens Serum Institut-
Descrição: dc.descriptionDepartment of Basic Sciences College of Veterinary Medicine Mississippi State University-
Descrição: dc.descriptionCollege of Science Health Engineering and Education Antimicrobial Resistance and Infectious Diseases Laboratory Murdoch University-
Descrição: dc.descriptionSydney School of Veterinary Science University of Sydney-
Descrição: dc.descriptionDepartment of Medical Microbiology University of Pretoria-
Descrição: dc.descriptionDepartment of Medical Microbiology Tshwane Academic Division National Health Laboratory Service-
Descrição: dc.descriptionInstituto de Investigaciones en Microbiología y Parasitología Médica University of Buenos Aires-CONICET-
Descrição: dc.descriptionMolecular Epidemiology College of Veterinary Medicine Ohio State University-
Descrição: dc.descriptionDepartment of Large Animal Clinical Sciences College of Veterinary Medicine Michigan State University-
Descrição: dc.descriptionDepartment of Nutrition and Animal Production School of Veterinary Medicine and Animal Sciences University of São Paulo, SP-
Descrição: dc.descriptionInstitute of Bioscience Universiti Putra Malaysia, Selangor-
Descrição: dc.descriptionDepartment of Microbiology and Immunology Institute of Biosciences São Paulo State University, SP-
Descrição: dc.descriptionAnimal & Bioscience Department, Teagasc, Grange, Dunsany-
Descrição: dc.descriptionThe Royal (Dick) School of Veterinary Studies University of Edinburgh-
Descrição: dc.descriptionDepartment of Veterinary Medicine University of Cambridge-
Descrição: dc.descriptionJanssen Immunology-
Descrição: dc.descriptionDepartment of Microbiology and Immunology Institute of Biosciences São Paulo State University, SP-
Idioma: dc.languageen-
Relação: dc.relationProceedings of the National Academy of Sciences of the United States of America-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectagriculture-
Palavras-chave: dc.subjecthost adaptation-
Palavras-chave: dc.subjectphylodynamics-
Palavras-chave: dc.subjectpopulation genomics-
Palavras-chave: dc.subjectStaphylococcus aureus-
Título: dc.titleMulticlonal human origin and global expansion of an endemic bacterial pathogen of livestock-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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