Circulating levels of tissue inhibitor of metalloproteinase 3, a protein with inhibitory effects on angiogenesis, are increased in pre-eclampsia

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Autor(es): dc.contributorUniversity of Mississippi Medical Center-
Autor(es): dc.contributorUniversidade Federal de Minas Gerais (UFMG)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorPalei, Ana C.-
Autor(es): dc.creatorCruz, Juliana de O.-
Autor(es): dc.creatorChaguri, João Leandro-
Autor(es): dc.creatorPeraçoli, José Carlos-
Autor(es): dc.creatorRomão-Veiga, Mariana-
Autor(es): dc.creatorRibeiro-Vasques, Vanessa R.-
Autor(es): dc.creatorCavalli, Ricardo C.-
Autor(es): dc.creatorNunes, Priscila R.-
Autor(es): dc.creatorLuizon, Marcelo R.-
Autor(es): dc.creatorSandrim, Valéria C.-
Data de aceite: dc.date.accessioned2025-08-21T16:14:10Z-
Data de disponibilização: dc.date.available2025-08-21T16:14:10Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-05-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1002/ijgo.14552-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/247987-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/247987-
Descrição: dc.descriptionObjective: To assess and compare circulating tissue inhibitor of metalloproteinase 3 (TIMP-3) concentrations between women with pre-eclampsia and healthy pregnant women. We also aimed to determine the relationships between circulating TIMP-3 and matrix metalloproteinase 2 (MMP-2), MMP-9, TIMP-1, and TIMP-2 concentrations in pre-eclampsia. Methods: A primary case–control study included patients with pre-eclampsia (n = 219) and gestational hypertension (n = 118), healthy pregnant women (n = 214), and non-pregnant women (n = 66), and a replication case–control study included patients with pre-eclampsia (n = 177) and healthy pregnant women (n = 124), all from southeastern Brazil. Plasma TIMP-3, MMP-2, MMP-9, TIMP-1, and TIMP-2 concentrations were assessed using commercially available enzyme-linked immunosorbent assay kits, and the relationships between them were analyzed using Spearman's correlation. Results: In our primary study, patients with pre-eclampsia and gestational hypertension exhibited increased TIMP-3 concentrations compared with healthy pregnant women (both P < 0.0001) and non-pregnant women (both P < 0.001). These findings were confirmed in the replication study, showing elevated TIMP-3 concentrations in women with pre-eclampsia versus healthy pregnant women (P < 0.001). We found no difference in TIMP-3 concentrations between early-onset and late-onset pre-eclampsia. Moreover, TIMP-3 concentrations were significantly correlated with plasma concentrations of TIMP-1 (r = 0.2333; P = 0.0086) and MMP-2 (r = 0.2159; P = 0.0156) in pre-eclampsia. Conclusions: Circulating TIMP-3 concentration is increased in women with pre-eclampsia compared with healthy pregnant women, and it is positively correlated with plasma MMP-2 and TIMP-1 concentrations in pre-eclampsia.-
Descrição: dc.descriptionFundação de Apoio ao Ensino, Pesquisa e Assistência do Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo-
Descrição: dc.descriptionNational Institutes of Health-
Descrição: dc.descriptionDepartment of Surgery School of Medicine University of Mississippi Medical Center-
Descrição: dc.descriptionCardiovascular-Renal Research Center University of Mississippi Medical Center-
Descrição: dc.descriptionDepartment of Genetics Ecology and Evolution Institute of Biological Sciences Federal University of Minas Gerais, Minas Gerais-
Descrição: dc.descriptionDepartment of Biophysics and Pharmacology Institute of Biosciences of Botucatu Sao Paulo State University (Unesp), Sao Paulo-
Descrição: dc.descriptionCenter of Toxicological Assistance (CEATOX) Institute of Biosciences of Botucatu Sao Paulo State University (Unesp), Sao Paulo-
Descrição: dc.descriptionDepartment of Gynecology and Obstetrics Botucatu Medical School Sao Paulo State University (Unesp), Sao Paulo-
Descrição: dc.descriptionDepartment of Chemistry and Biological Sciences Institute of Biosciences of Botucatu Sao Paulo State University (Unesp), Sao Paulo-
Descrição: dc.descriptionDepartment of Gynecology and Obstetrics Faculty of Medicine of Ribeirao Preto University of Sao Paulo (USP), Sao Paulo-
Descrição: dc.descriptionDepartment of Biophysics and Pharmacology Institute of Biosciences of Botucatu Sao Paulo State University (Unesp), Sao Paulo-
Descrição: dc.descriptionCenter of Toxicological Assistance (CEATOX) Institute of Biosciences of Botucatu Sao Paulo State University (Unesp), Sao Paulo-
Descrição: dc.descriptionDepartment of Gynecology and Obstetrics Botucatu Medical School Sao Paulo State University (Unesp), Sao Paulo-
Descrição: dc.descriptionDepartment of Chemistry and Biological Sciences Institute of Biosciences of Botucatu Sao Paulo State University (Unesp), Sao Paulo-
Descrição: dc.descriptionNational Institutes of Health: R01HL148191-
Descrição: dc.descriptionNational Institutes of Health: U54GM115428-
Formato: dc.format544-551-
Idioma: dc.languageen-
Relação: dc.relationInternational Journal of Gynecology and Obstetrics-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectgestational hypertension-
Palavras-chave: dc.subjectmatrix metalloproteinase-2-
Palavras-chave: dc.subjectpre-eclampsia-
Palavras-chave: dc.subjecttissue inhibitor of metalloproteinase 1-
Palavras-chave: dc.subjecttissue inhibitor of metalloproteinase 3-
Título: dc.titleCirculating levels of tissue inhibitor of metalloproteinase 3, a protein with inhibitory effects on angiogenesis, are increased in pre-eclampsia-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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