Evaluation of cytotoxicity and genotoxicity of a novel oxovanadium complex with orotate

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUNIARA – University of Araraquara-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorda Silva Gomes, Pietra Stefany-
Autor(es): dc.creatorda Silva, Washington Wilson-
Autor(es): dc.creatorde Cássia Gasparoti, Gabriela-
Autor(es): dc.creatorPayolla, Filipe Boccato-
Autor(es): dc.creatorde Oliveira, Jonata Augusto-
Autor(es): dc.creatorBarbugli, Paula Aboud-
Autor(es): dc.creatorMarin-Dett, Freddy Humberto-
Autor(es): dc.creatorCavicchioli, Maurício-
Autor(es): dc.creatorMassabni, Antonio Carlos-
Autor(es): dc.creatorResende, Flávia Aparecida-
Data de aceite: dc.date.accessioned2025-08-21T23:43:50Z-
Data de disponibilização: dc.date.available2025-08-21T23:43:50Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2022-10-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.mrgentox.2022.503558-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/247983-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/247983-
Descrição: dc.descriptionThe development of new drugs based on metal complexes requires a detailed analysis of their biological endpoints. In this study, we report the genotoxic profile and influence on cell proliferation and death of the oxovanadium(IV) complex with orotic acid ([VO(C5H4N2O4)2], VO(oro)). Human hepatocellular carcinoma cells (HepG2) were the most sensitive tumor cells to VO(oro), which interfered with the integrity of cell membranes and proliferative capacity in a dose-dependent manner, inducing cell death by apoptosis. Regarding genotoxicity, VO(oro) did not induce considerable levels of DNA damage in HepG2 cells (comet test) and gene mutations (Ames test). However, it caused a statistically significant increase in the frequency of micronuclei at the highest concentration tested (12.5 µmol.L–1), indicating aneuploidy and clastogenicity. The data presented here provide information on various biological aspects of the VO(oro) complex, which may allow the elucidation of its mechanism of action as a possible therapeutic agent.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionUNIARA – University of Araraquara Department of Biological Sciences and Health, São Paulo-
Descrição: dc.descriptionUNESP – São Paulo State University Faculty of Pharmaceutical Sciences of Araraquara Department of Natural Active Principles and Toxicology, São Paulo-
Descrição: dc.descriptionUNESP – São Paulo State University School of Dentistry of Araraquara, São Paulo-
Descrição: dc.descriptionUNESP – São Paulo State University Faculty of Pharmaceutical Sciences of Araraquara Department of Natural Active Principles and Toxicology, São Paulo-
Descrição: dc.descriptionUNESP – São Paulo State University School of Dentistry of Araraquara, São Paulo-
Descrição: dc.descriptionFAPESP: 2013/09265-7-
Descrição: dc.descriptionFAPESP: 2017/16278-9-
Descrição: dc.descriptionCAPES: 88887.335189/2019-00-
Idioma: dc.languageen-
Relação: dc.relationMutation Research - Genetic Toxicology and Environmental Mutagenesis-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCytotoxicity-
Palavras-chave: dc.subjectGenomic instability-
Palavras-chave: dc.subjectMutagenicity-
Palavras-chave: dc.subjectOxovanadium complex-
Palavras-chave: dc.subjectToxicogenetics-
Título: dc.titleEvaluation of cytotoxicity and genotoxicity of a novel oxovanadium complex with orotate-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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