Neutrophil/lymphocyte ratio and other blood cell component counts are not associated with the development of postmolar gestational trophoblastic neoplasia

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Autor(es): dc.contributorMaternity School of Rio de Janeiro Federal University-
Autor(es): dc.contributorFaculty of Medicine of Fluminense Federal University-
Autor(es): dc.contributorYoung Leadership Physicians Program-
Autor(es): dc.contributorVassouras University-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorHospital Moinhos de Vento-
Autor(es): dc.contributorHarvard Medical School-
Autor(es): dc.creatorBraga, Antonio-
Autor(es): dc.creatorCanelas, Ana Clara-
Autor(es): dc.creatorTorres, Berenice-
Autor(es): dc.creatorMaesta, Izildinha-
Autor(es): dc.creatorGiongo Pedrotti, Luana-
Autor(es): dc.creatorBessel, Marina-
Autor(es): dc.creatorVieira Dos Santos Esteves, Ana Paula-
Autor(es): dc.creatorAmim Junior, Joffre-
Autor(es): dc.creatorRezende Filho, Jorge-
Autor(es): dc.creatorElias, Kevin M.-
Autor(es): dc.creatorHorowitz, Neil S.-
Autor(es): dc.creatorBerkowitz, Ross S.-
Data de aceite: dc.date.accessioned2025-08-21T22:50:30Z-
Data de disponibilização: dc.date.available2025-08-21T22:50:30Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2021-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1371/journal.pone.0277892-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/247975-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/247975-
Descrição: dc.descriptionOBJECTIVE: To relate preevacuation platelet count and leukogram findings, especially neutrophil/lymphocyte ratios (NLR) and platelet/lymphocyte ratios with the occurrence of gestational trophoblastic neoplasia (GTN) after complete hydatidiform mole (CHM) among Brazilian women. METHODS: Retrospective cohort study of patients with CHM followed at Rio de Janeiro Federal University, from January/2015-December/2020. Before molar evacuation, all patients underwent a medical evaluation, complete blood count and hCG measurement, in addition to other routine preoperative tests. The primary outcome was the occurrence of postmolar GTN. RESULTS: From 827 cases of CHM treated initially at the Reference Center, 696 (84.15%) had spontaneous remission and 131 (15.85%) developed postmolar GTN. Using optimal cut-offs from receiver operating characteristic curves and multivariable logistic regression adjusted for the possible confounding variables of age and preevacuation hCG level (already known to be associated with the development of GTN) we found that ≥2 medical complications at presentation (aOR: 1.96, CI 95%: 1.29-2.98, p<0.001) and preevacuation hCG ≥100,000 IU/L (aOR: 2.16, CI 95%: 1.32-3.52, p<0.001) were significantly associated with postmolar GTN after CHM. However, no blood count profile findings were able to predict progression from CHM to GTN. CONCLUSION: Although blood count is a widely available test, being a low-cost test and mandatory before molar evacuation, and prognostic for outcome in other neoplasms, its findings were not able to predict the occurrence of GTN after CHM. In contrast, the occurrence of medical complications at presentation and higher preevacuation hCG levels were significantly associated with postmolar GTN and may be useful to guide individualized clinical decisions in post-molar follow-up and treatment of these patients.-
Descrição: dc.descriptionDepartment of Obstetrics and Gynecology Postgraduate Program in Perinatal Health Faculty of Medicine Maternity School of Rio de Janeiro Federal University-
Descrição: dc.descriptionDepartment of Maternal Child Health Postgraduate Program in Medical Sciences Faculty of Medicine of Fluminense Federal University-
Descrição: dc.descriptionNational Academy of Medicine Young Leadership Physicians Program-
Descrição: dc.descriptionPostgraduate Program in Applied Health Sciences Vassouras University-
Descrição: dc.descriptionDepartment of Gynecology and Obstetrics Botucatu Trophoblastic Disease Center of the Clinical Hospital of Botucatu Medical School São Paulo State University - UNESP-
Descrição: dc.descriptionHospital Moinhos de Vento-
Descrição: dc.descriptionDepartment of Obstetrics Gynecology and Reproductive Biology New England Trophoblastic Disease Center Division of Gynecologic Oncology Brigham and Women's Hospital Harvard Medical School-
Descrição: dc.descriptionDepartment of Gynecology and Obstetrics Botucatu Trophoblastic Disease Center of the Clinical Hospital of Botucatu Medical School São Paulo State University - UNESP-
Formato: dc.formate0277892-
Idioma: dc.languageen-
Relação: dc.relationPloS one-
???dc.source???: dc.sourceScopus-
Título: dc.titleNeutrophil/lymphocyte ratio and other blood cell component counts are not associated with the development of postmolar gestational trophoblastic neoplasia-
Tipo de arquivo: dc.typelivro digital-
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