Transcriptional profiles and common genes link lung cancer with the development and severity of COVID-19

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorRegional Blood Center of Ribeirão Preto-
Autor(es): dc.contributorInstitute for Cancer Research (IPEC)-
Autor(es): dc.contributorUniversal Scientific Education and Research Network (USERN)-
Autor(es): dc.contributorFederal University of Rio Grande do Norte (UFRN)-
Autor(es): dc.contributorLead Contact-
Autor(es): dc.creatorCury, S. S.-
Autor(es): dc.creatorOliveira, J. S.-
Autor(es): dc.creatorBiagi-Júnior, C. A.O.-
Autor(es): dc.creatorSilva, W. A.-
Autor(es): dc.creatorReis, P. P.-
Autor(es): dc.creatorCabral-Marques, O.-
Autor(es): dc.creatorHasimoto, E. N.-
Autor(es): dc.creatorFreire, P. P.-
Autor(es): dc.creatorCarvalho, R. F.-
Data de aceite: dc.date.accessioned2025-08-21T21:44:18Z-
Data de disponibilização: dc.date.available2025-08-21T21:44:18Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-02-04-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.gene.2022.147047-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/247964-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/247964-
Descrição: dc.descriptionLung cancer patients with COVID-19 present an increased risk of developing severe disease and, consequently, have poor outcomes. Determining SARS-CoV-2-host interactome in lung cancer cells and tissues, infected or uninfected with SARS-CoV-2, may reveal molecular mechanisms associated with COVID-19 development and severity in lung cancer patients. Here, we integrated transcriptome data of lung tumors from patients with small- or non-small cell lung cancer (SCLC and NSCLC) and normal lung and lung cancer cells infected with SARS-CoV-2. We aimed to characterize molecular mechanisms potentially associated with COVID-19 development and severity in lung cancer patients and to predict the SARS-CoV-2-host cell interactome. We found that the gene expression profiles of lung cell lines infected with SARS-CoV-2 resemble more primary lung tumors than non-malignant lung tissues. In addition, the transcriptomic-based interactome analysis of SCLC and NSCLC revealed increased expression of cancer genes BRCA1 and CENPF, whose proteins are known or predicted to interact with the SARS-CoV-2 spike glycoprotein and helicase, respectively. We also found that TRIB3, a gene coding a putative host-SARS-CoV-2 interacting protein associated with COVID-19 infection, is co-expressed with the up-regulated genes MTHFD2, ADM2, and GPT2 in all tested conditions. Our analysis identified biological processes such as amino acid metabolism and angiogenesis and 22 host mediators of SARS-CoV-2 infection and replication that may contribute to the development and severity of COVID-19 in lung cancers.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences São Paulo State University (UNESP), Botucatu, SP-
Descrição: dc.descriptionDepartment of Genetics Ribeirão Preto Medical School University of São Paulo (USP), SP-
Descrição: dc.descriptionCenter for Cell-Based Therapy (CEPID/FAPESP) National Institute of Science and Technology in Stem Cell and Cell Therapy (INCTC/CNPq) Regional Blood Center of Ribeirão Preto, SP-
Descrição: dc.descriptionInstitute for Cancer Research (IPEC), PR-
Descrição: dc.descriptionDepartment of Surgery and Orthopedics Faculty of Medicine São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Immunology Institute of Biomedical Sciences University of São Paulo, SP-
Descrição: dc.descriptionDepartment of Clinical and Toxicological Analyses School of Pharmaceutical Sciences University of São Paulo (USP), SP-
Descrição: dc.descriptionNetwork of Immunity in Infection Malignancy and Autoimmunity (NIIMA) Universal Scientific Education and Research Network (USERN), SP-
Descrição: dc.descriptionDepartment of Pharmacy and Postgraduate Program of Health and Science Federal University of Rio Grande do Norte (UFRN), RN-
Descrição: dc.descriptionLead Contact-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences São Paulo State University (UNESP), Botucatu, SP-
Descrição: dc.descriptionDepartment of Surgery and Orthopedics Faculty of Medicine São Paulo State University (UNESP), SP-
Idioma: dc.languageen-
Relação: dc.relationGene-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectA549-
Palavras-chave: dc.subjectCalu-3-
Palavras-chave: dc.subjectHost-virus interactome-
Palavras-chave: dc.subjectNSCLC-
Palavras-chave: dc.subjectSARS-CoV-2-
Palavras-chave: dc.subjectSCLC-
Título: dc.titleTranscriptional profiles and common genes link lung cancer with the development and severity of COVID-19-
Tipo de arquivo: dc.typelivro digital-
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