Circulating miRNAs are associated with frailty and ST-elevation myocardial infarction pathways

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorComplexo Hospitalar Santa Genoveva de Uberlândia-
Autor(es): dc.contributorUniversity of Nottingham-
Autor(es): dc.creatorRamos, Juan Thomaz Gabriel de Souza-
Autor(es): dc.creatorPereira, Amanda Gomes-
Autor(es): dc.creatorFerrari, Felipe Sanches-
Autor(es): dc.creatorAndrade, Morganna Freitas-
Autor(es): dc.creatorde Melo, Caroline Souto-
Autor(es): dc.creatorBoas, Paulo José Fortes Villas-
Autor(es): dc.creatorFelix, Tainara F.-
Autor(es): dc.creatorde Carvalho, Marcio-
Autor(es): dc.creatorDorna, Mariana Souza-
Autor(es): dc.creatorAzevedo, Paula Schmidt-
Autor(es): dc.creatorPhillips, Bethan E.-
Autor(es): dc.creatorPolegato, Bertha Furlan-
Autor(es): dc.creatorOkoshi, Katashi-
Autor(es): dc.creatorBazan, Silmeia Garcia Zanati-
Autor(es): dc.creatorPaiva, Sergio Alberto Rupp-
Autor(es): dc.creatorZornoff, Leonardo Antonio Mamede-
Autor(es): dc.creatorReis, Patricia P.-
Autor(es): dc.creatorMinicucci, Marcos Ferreira-
Data de aceite: dc.date.accessioned2025-08-21T18:01:14Z-
Data de disponibilização: dc.date.available2025-08-21T18:01:14Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.archger.2022.104870-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/247950-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/247950-
Descrição: dc.descriptionBackground: Frailty and ST-Elevation Myocardial Infarction (STEMI) share similar molecular pathways. Specific biomarkers, such as microRNAs (miRNAs), may provide insights into the molecular mechanisms that cause the relationship between frailty and STEMI. Objective: Our aim was to identify and compare circulating miRNA levels between frail and non-frail older adults following STEMI and comprehend the regulatory miRNA-gene networks and pathways involved in this condition. Methods: This exploratory study is a subanalysis of a larger observational study. In this study, we selected patients ≥ 65 years old, following STEMI, with pre-frail/frail (n=5) and non-frail (n=4) phenotype evaluated using the Clinical Frailty Scale and serum circulating miRNA levels were analyzed. Results: Pre-frail/frail patients had greater serum levels of 53 miRNAs, compared with non-frail patients. Notably, miR-103a-3p, miR-598-3p, and miR-130a-3p were the top three significantly deregulated miRNAs predicted to modulate gene expression associated with aging. Additional computational analyses showed 7,420 predicted miRNA gene targets, which were regulated by at least two of the 53 identified miRNAs. Pathway enrichment analysis showed that axon guidance and MAPK signaling were among pathways regulated by miRNA target genes. Conclusions: These novel findings suggest a correlation between the identified miRNAs, target genes, and pathways in pre-frail and frail patients with myocardial infarction.-
Descrição: dc.descriptionSão Paulo State University (Unesp) Medical School Internal Medicine Department-
Descrição: dc.descriptionDepartment of Anesthesiology Complexo Hospitalar Santa Genoveva de Uberlândia-
Descrição: dc.descriptionSão Paulo State University (Unesp) Medical School Experimental Research Unit (UNIPEX)-
Descrição: dc.descriptionMedical Research Council-Versus Arthritis Centre for Musculoskeletal Ageing Research and National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre University of Nottingham, Derby-
Descrição: dc.descriptionSão Paulo State University (Unesp) Medical School Department of Surgery and Orthopedics-
Descrição: dc.descriptionSão Paulo State University (Unesp) Medical School Internal Medicine Department-
Descrição: dc.descriptionSão Paulo State University (Unesp) Medical School Experimental Research Unit (UNIPEX)-
Descrição: dc.descriptionSão Paulo State University (Unesp) Medical School Department of Surgery and Orthopedics-
Idioma: dc.languageen-
Relação: dc.relationArchives of Gerontology and Geriatrics-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectFrailty-
Palavras-chave: dc.subjectmicroRNA-
Palavras-chave: dc.subjectMolecular pathways-
Palavras-chave: dc.subjectMyocardial infarction-
Título: dc.titleCirculating miRNAs are associated with frailty and ST-elevation myocardial infarction pathways-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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