Advances in the crosstalk between maternal separation and voluntary ethanol consumption and effects on reproduction

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Federal de Santa Catarina (UFSC)-
Autor(es): dc.creatorTeixeira, Giovana Rampazzo-
Autor(es): dc.creatorMartins, Otávio Augusto-
Autor(es): dc.creatorKremer, Rafael-
Autor(es): dc.creatorVeras, Allice Santos Cruz-
Autor(es): dc.creatorPinheiro, Patricia Fernanda Felipe-
Autor(es): dc.creatorMello-Junior, Wilson-
Autor(es): dc.creatorMartinez, Francisco Eduardo-
Data de aceite: dc.date.accessioned2025-08-21T22:44:27Z-
Data de disponibilização: dc.date.available2025-08-21T22:44:27Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2022-12-14-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.lfs.2022.121173-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/247894-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/247894-
Descrição: dc.descriptionMaternal separation (SM) is an event caused by early stress and may be associated with behavioral changes and vulnerabilities, enhancing ethanol consumption in adulthood. The aim of the study was to evaluate whether MS potentiates the effects of ethanol ingestion on physiological hormone regulation and its interference in testicular and epididymal morphofunctional aspects in voluntary ethanol-consuming rats. Therefore, for the first time, we investigated the effect of maternal separation and ethanol consumption in adulthood and for this we used free choice ethanol-consuming strains. Responses of metabolic and hormonal parameters were also addressed, as well as their effects on reproductive function. In summary, MS promoted an increase in voluntary ethanol consumption in UChA and UChB animals. There was an influence of MS on the increase of circulating corticosterone and testosterone in UChB animals (high-ethanol-preferring 10 % v/v). MS performed in the hyporesponsive period to stress promoted an increase in glucose and circulating lipids, as well as a reduction in lactate dehydrogenase levels. Daily sperm production and transit time through the epididymis in UChB animals were increased by MS. Together, these findings show that MS potentiates the effects of ethanol ingestion and promotes an imbalance in plasma hormone concentrations, interfering with the reproductive functional imbalance of ethanol-consuming rats.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Physical Education School of Technology and Sciences UNESP Campus of Presidente Prudente, SP-
Descrição: dc.descriptionDepartment of Cellular Biology Embryology Genetics - Federal University of Santa Catarina, Santa Catarina-
Descrição: dc.descriptionDepartment of Medicine - Federal University of Fronteira Sul, Rio Grande do Sul-
Descrição: dc.descriptionMulticenter Graduate Program in Physiological Sciences SBFIS São Paulo State University (UNESP), Campus of Araçatuba, SP-
Descrição: dc.descriptionDepartment of Animal Production and Preventive Veterinary Medicine Faculty of Veterinary Medicine and Animal Science São Paulo State University (UNESP) -, SP-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Physical Education School of Technology and Sciences UNESP Campus of Presidente Prudente, SP-
Descrição: dc.descriptionMulticenter Graduate Program in Physiological Sciences SBFIS São Paulo State University (UNESP), Campus of Araçatuba, SP-
Descrição: dc.descriptionDepartment of Animal Production and Preventive Veterinary Medicine Faculty of Veterinary Medicine and Animal Science São Paulo State University (UNESP) -, SP-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences São Paulo State University (UNESP), SP-
Descrição: dc.descriptionFAPESP: 2005/04712-1-
Descrição: dc.descriptionFAPESP: 2020/16166-9-
Descrição: dc.descriptionFAPESP: 2020/16310-2-
Idioma: dc.languageen-
Relação: dc.relationLife Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAlcohol-induced disorders-
Palavras-chave: dc.subjectCorticosterone-
Palavras-chave: dc.subjectEarly-life stress-
Palavras-chave: dc.subjectPituitary-adrenal system-
Título: dc.titleAdvances in the crosstalk between maternal separation and voluntary ethanol consumption and effects on reproduction-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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