Pomegranate Extract Potentiates the Anti-Demineralizing, Anti-Biofilm, and Anti-Inflammatory Actions of Non-Alcoholic Mouthwash When Associated with Sodium-Fluoride Trimetaphosphate

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Ribeirão Preto—UNAERP-
Autor(es): dc.contributorApis Flora Industrial and Comercial Ltd-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorNational Institute for Agrarian and Veterinary Research-
Autor(es): dc.creatorFernandes, Gabriela Lopes-
Autor(es): dc.creatorVieira, Ana Paula Miranda-
Autor(es): dc.creatorDanelon, Marcelle-
Autor(es): dc.creatorEmerenciano, Nayara Gonçalves-
Autor(es): dc.creatorBerretta, Andresa Aparecida-
Autor(es): dc.creatorBuszinski, Andrei Felipe Moreira-
Autor(es): dc.creatorHori, Juliana Issa-
Autor(es): dc.creatorLima, Mikhael Haruo Fernandes de-
Autor(es): dc.creatorReis, Thaila Fernanda dos-
Autor(es): dc.creatorLima, Jessica Aparecida de-
Autor(es): dc.creatorDelbem, Alberto Carlos Botazzo-
Autor(es): dc.creatorSilva, Sónia Carina Morais da-
Autor(es): dc.creatorBarbosa, Debora Barros-
Data de aceite: dc.date.accessioned2025-08-21T18:56:54Z-
Data de disponibilização: dc.date.available2025-08-21T18:56:54Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2022-10-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/antibiotics11111477-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/247858-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/247858-
Descrição: dc.descriptionThis study investigated the anti-caries and anti-inflammatory effects of mouthwash formulations containing Punica granatum (pomegranate) peel extract (PPE), sodium-trimetaphosphate, and low concentrations of fluoride. PPE was characterized using high-performance liquid chromatography (ellagic acid and punicalagin). Total phenolics were quantified among formulations, and their stability was analyzed for 28 days. The formulation effects were evaluated as follows: (1) inorganic component concentration and reduced demineralization on bovine enamel blocks subjected to pH cycling; (2) anti-biofilm effect on dual-biofilms of Streptococcus mutans ATCC 25175 and Candida albicans ATCC 10231 treated for 1 and 10 min, respectively; and (3) cytotoxicity and production of inflammatory mediators (interleukin-6 and tumor necrosis factor-alpha). The formulation containing 3% PPE, 0.3% sodium-trimetaphosphate, and 225 ppm of fluoride resulted in a 34.5% surface hardness loss; a 13% (treated for 1 min) and 36% (treated for 10 min) biofilm reduction in S. mutans; a 26% (1 min) and 36% (10 min) biofilm reduction in C. albicans; absence of cytotoxicity; and anti-inflammatory activity confirmed by decreased interleukin-6 production in mouse macrophages. Thus, our results provide a promising prospect for the development of an alcohol-free commercial dental product with the health benefits of P. granatum that have been recognized for a millennium.-
Descrição: dc.descriptionGraduate Program of Dental Science School of Dentistry Araçatuba São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionSchool of Dentistry University of Ribeirão Preto—UNAERP, São Paulo-
Descrição: dc.descriptionDepartment of Restorative Dentistry School of Dentistry Araçatuba São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionApis Flora Industrial and Comercial Ltd, São Paulo-
Descrição: dc.descriptionDepartment of Biochemistry and Immunology University of São Paulo Ribeirão Preto-
Descrição: dc.descriptionDepartment of Dental Materials and Prosthodontics School of Dentistry Araçatuba São Paulo State University (UNESP)-
Descrição: dc.descriptionNational Institute for Agrarian and Veterinary Research, Vairão-
Descrição: dc.descriptionGraduate Program of Dental Science School of Dentistry Araçatuba São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionDepartment of Restorative Dentistry School of Dentistry Araçatuba São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionDepartment of Dental Materials and Prosthodontics School of Dentistry Araçatuba São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationAntibiotics-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectanti-inflammatory-
Palavras-chave: dc.subjectantimicrobial-
Palavras-chave: dc.subjectdental enamel-
Palavras-chave: dc.subjectfluoride-
Palavras-chave: dc.subjectpolyphosphates-
Palavras-chave: dc.subjectPunica granatum-
Título: dc.titlePomegranate Extract Potentiates the Anti-Demineralizing, Anti-Biofilm, and Anti-Inflammatory Actions of Non-Alcoholic Mouthwash When Associated with Sodium-Fluoride Trimetaphosphate-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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