Genome-wide association study of host resistance to the ectoparasite Ichthyophthirius multifiliis in the Amazon fish Colossoma macropomum

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidad de Chile-
Autor(es): dc.creatorLira, Lieschen V. G.-
Autor(es): dc.creatorMastrochirico-Filho, Vito A.-
Autor(es): dc.creatorMendes, Natalia J.-
Autor(es): dc.creatorAriede, Raquel B.-
Autor(es): dc.creatorYáñez, José M.-
Autor(es): dc.creatorHashimoto, Diogo T.-
Data de aceite: dc.date.accessioned2025-08-21T20:10:53Z-
Data de disponibilização: dc.date.available2025-08-21T20:10:53Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2022-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s11033-022-08062-0-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/247853-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/247853-
Descrição: dc.descriptionBackground: Tambaqui, Colossoma macropomum, is the most important native fish species farmed in South America, particularly in Brazil, where its production is limited in the southern and southeastern regions due to disease outbreaks caused by the parasite Ichthyophthirius multifiliis. Therefore, genome level analysis to understand the genetic architecture of the host resistance against I. multifiliis is fundamental to improve this trait in tambaqui. The objective of the present study was to map QTL (quantitative trait loci) associated with resistance to I. multifiliis in tambaqui by GWAS (genome-wide association study). Methods and results: Individuals belonging to seven families, which were previously submitted to an experimental challenge to assess the natural resistance to the parasite I. multifiliis, were used for genomic analysis. A total of 7717 SNPs were identified in this population by ddRAD (double digest restriction site associated DNA). GWAS revealed four SNPs significantly associated in the LGs (linkage groups) 2, 9, 11 and 20 for the traits time of death and parasite load. The SNPs explained a low proportion of the variance to I. multifiliis resistance for time of death and parasite load (about 0.622% and 0.375%, respectively). The SNPs were close to 11 genes related to the immune system: abcf3, znf830, ccr9, gli3, ackr4, tbata, ndr2, tgfbr3, nhej1, znf644b, and cldn10a. Conclusions: In conclusion, the resistance to I. multifiliis is probably under polygenic control in tambaqui, in which different QTLs of low variance can be involved in the immune responses against this ectoparasite.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionAquaculture Center of Unesp São Paulo State University (Unesp), Via de Acesso Prof. Paulo Donato Castellane, s/n, SP-
Descrição: dc.descriptionFacultad de Ciencias Veterinarias y Pecuarias Universidad de Chile-
Descrição: dc.descriptionAquaculture Center of Unesp São Paulo State University (Unesp), Via de Acesso Prof. Paulo Donato Castellane, s/n, SP-
Descrição: dc.descriptionCAPES: 1681749-
Descrição: dc.descriptionCNPq: 311559/2018-2-
Descrição: dc.descriptionCNPq: 422670/2018-9-
Formato: dc.format599-607-
Idioma: dc.languageen-
Relação: dc.relationMolecular Biology Reports-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBreeding program-
Palavras-chave: dc.subjectDisease resistance-
Palavras-chave: dc.subjectGWAS-
Palavras-chave: dc.subjectQTLs-
Palavras-chave: dc.subjectSNPs-
Título: dc.titleGenome-wide association study of host resistance to the ectoparasite Ichthyophthirius multifiliis in the Amazon fish Colossoma macropomum-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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