Gels containing statherin-derived peptide protect against enamel and dentin erosive tooth wear in vitro

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorFederal University of ABC-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorReis, Fabiana Navas-
Autor(es): dc.creatorFrancese, Monique Malta-
Autor(es): dc.creatorSilva, Natara Dias Gomes da-
Autor(es): dc.creatorPelá, Vinicius Taioqui-
Autor(es): dc.creatorCâmara, João Victor Frazão-
Autor(es): dc.creatorTrevizol, Juliana Sanches-
Autor(es): dc.creatorPieretti, Joana Claudio-
Autor(es): dc.creatorSeabra, Amedea Barozzi-
Autor(es): dc.creatorPessan, Juliano Pelim-
Autor(es): dc.creatorHonório, Heitor Marques-
Autor(es): dc.creatorCrusca, Edson-
Autor(es): dc.creatorMarchetto, Reinaldo-
Autor(es): dc.creatorBuzalaf, Marília Afonso Rabelo-
Data de aceite: dc.date.accessioned2025-08-21T18:25:15Z-
Data de disponibilização: dc.date.available2025-08-21T18:25:15Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2022-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.jmbbm.2022.105549-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/247849-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/247849-
Descrição: dc.descriptionThe effect of gels containing a statherin-derived peptide (Stn) on the protection against enamel and dentin erosive tooth wear (ETW) in vitro was evaluated. Bovine enamel and dentin specimens were divided into 2 groups (n = 15 and 18/group for enamel and dentin, respectively) that were treated with Chitosan or Carboxymethylcellulose (CMC) gels containing Stn15pSpS at 1.88 × 10-5 M or 3.76 × 10-5 M. Chitosan or CMC gels without active ingredients served as negative controls, while chitosan gel containing 1.23% F (as NaF) and acidulated phosphate fluoride gel (1.23% F) served as positive controls. The gels were applied on the specimens for 4 min. Stimulated saliva was collected from 3 donors and used to form a 2-h acquired pellicle on the specimens. Then, the specimens were submitted to an erosive pH cycling protocol 4 times/day for 7 days (0.01 M HCl pH 2.0/45 s, artificial saliva/2 h, and artificial saliva overnight). The gels were applied again during pH cycling, 2 times/day for 4 min after the first and last erosive challenges. Enamel and dentin loss (μm) were assessed by contact profilometry. Scanning electron microscopy (SEM) was analyzed using a cold field emission. Data were analyzed by two-way ANOVA (for chitosan and CMC gels, separately) and Tukey's multiple comparison test. SEM images showed changes to enamel topography after application oft the gels containing Stn or F. Regarding CMC-based gels, for enamel, none of the treatments significantly reduced ETW in comparison with placebo; for dentin, however, gels containing Stn, regardless the concentration, significantly reduced the ETW. Moreover, Chitosan-based gels, regardless the Stn concentration, were able to protect enamel and dentin against ETW. Gels containing Stn might be a new approach to protect against ETW.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Biological Sciences Bauru School of Dentistry University of São Paulo-
Descrição: dc.descriptionCenter for Natural and Human Sciences Federal University of ABC-
Descrição: dc.descriptionDepartment of Pediatric Dentistry and Public Health Araçatuba Dental School São Paulo State University UNESP, Araçatuba-
Descrição: dc.descriptionChemistry Institute Paulista State University-
Descrição: dc.descriptionDepartment of Pediatric Dentistry and Public Health Araçatuba Dental School São Paulo State University UNESP, Araçatuba-
Descrição: dc.descriptionChemistry Institute Paulista State University-
Descrição: dc.descriptionFAPESP: 2019/26070–1-
Idioma: dc.languageen-
Relação: dc.relationJournal of the Mechanical Behavior of Biomedical Materials-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectDental pellicle-
Palavras-chave: dc.subjectHuman-
Palavras-chave: dc.subjectStatherin protein-
Palavras-chave: dc.subjectTooth erosion-
Título: dc.titleGels containing statherin-derived peptide protect against enamel and dentin erosive tooth wear in vitro-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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