Small Extracellular Vesicles from Hypoxic Triple-Negative Breast Cancer Cells Induce Oxygen-Dependent Cell Invasion

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Autor(es): dc.contributorUniversidade Federal de São Carlos (UFSCar)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorBarretos Cancer Hospital-
Autor(es): dc.creatorPachane, Bianca Cruz-
Autor(es): dc.creatorNunes, Ana Carolina Caetano-
Autor(es): dc.creatorCataldi, Thais Regiani-
Autor(es): dc.creatorMicocci, Kelli Cristina-
Autor(es): dc.creatorMoreira, Bianca Caruso-
Autor(es): dc.creatorLabate, Carlos Alberto-
Autor(es): dc.creatorSelistre-de-Araujo, Heloisa Sobreiro-
Autor(es): dc.creatorAltei, Wanessa Fernanda-
Data de aceite: dc.date.accessioned2025-08-21T23:46:03Z-
Data de disponibilização: dc.date.available2025-08-21T23:46:03Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2022-10-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/ijms232012646-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/247820-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/247820-
Descrição: dc.descriptionHypoxia, a condition of low oxygenation frequently found in triple-negative breast tumors (TNBC), promotes extracellular vesicle (EV) secretion and favors cell invasion, a complex process in which cell morphology is altered, dynamic focal adhesion spots are created, and ECM is remodeled. Here, we investigated the invasive properties triggered by TNBC-derived hypoxic small EV (SEVh) in vitro in cells cultured under hypoxic (1% O2) and normoxic (20% O2) conditions, using phenotypical and proteomic approaches. SEVh characterization demonstrated increased protein abundance and diversity over normoxic SEV (SEVn), with enrichment in pro-invasive pathways. In normoxic cells, SEVh promotes invasive behavior through pro-migratory morphology, invadopodia development, ECM degradation, and matrix metalloprotease (MMP) secretion. The proteome profiling of 20% O2-cultured cells exposed to SEVh determined enrichment in metabolic processes and cell cycles, modulating cell health to escape apoptotic pathways. In hypoxia, SEVh was responsible for proteolytic and catabolic pathway inducement, interfering with integrin availability and gelatinase expression. Overall, our results demonstrate the importance of hypoxic signaling via SEV in tumors for the early establishment of metastasis.-
Descrição: dc.descriptionBiochemistry and Molecular Biology Laboratory Department of Physiological Sciences Universidade Federal de São Carlos—UFSCar, SP-
Descrição: dc.descriptionMax Feffer Plant Genetics Laboratory Department of Genetics University of São Paulo—ESALQ, SP-
Descrição: dc.descriptionCenter for the Study of Social Insects São Paulo State University “Julio de Mesquita Filho”, SP-
Descrição: dc.descriptionMolecular Oncology Research Center Barretos Cancer Hospital, SP-
Descrição: dc.descriptionRadiation Oncology Department Barretos Cancer Hospital, SP-
Descrição: dc.descriptionCenter for the Study of Social Insects São Paulo State University “Julio de Mesquita Filho”, SP-
Idioma: dc.languageen-
Relação: dc.relationInternational Journal of Molecular Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectbreast cancer-
Palavras-chave: dc.subjectcell invasion-
Palavras-chave: dc.subjectextracellular vesicles-
Palavras-chave: dc.subjecthypoxia-
Título: dc.titleSmall Extracellular Vesicles from Hypoxic Triple-Negative Breast Cancer Cells Induce Oxygen-Dependent Cell Invasion-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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