Efficacy and safety of morphine and methadone as analgesics in a balanced anaesthetic protocol in rabbits

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Autor(es): dc.contributorUniversidade Federal de Viçosa (UFV)-
Autor(es): dc.contributorUniversidad CES-
Autor(es): dc.contributorCorregimiento San José del Nus-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUnião das Faculdades dos Grandes Lagos-
Autor(es): dc.creatorNobre, Camila Vieira-
Autor(es): dc.creatorUscategui, Ricardo A.R.-
Autor(es): dc.creatorNoriega, Jorge-
Autor(es): dc.creatorGasser, Beatriz-
Autor(es): dc.creatorPazzini, Josiane Morais-
Autor(es): dc.creatorde Almeida, Vívian Tavares-
Autor(es): dc.creatorde Nardi, Andrigo Barboza-
Autor(es): dc.creatorde Andrade, James Newton-
Data de aceite: dc.date.accessioned2025-08-21T17:14:15Z-
Data de disponibilização: dc.date.available2025-08-21T17:14:15Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2021-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.15381/rivep.v33i4.23358-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/247801-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/247801-
Descrição: dc.descriptionThe efficacy of preventive analgesia and the cardiopulmonary effects of morphine or methadone in rabbits undergoing experimental skin surgery were evaluated and compared. Thirty-six rabbits were randomly assigned to three experimental groups: Control, Morphine, and Methadone. The rabbits received midazolam 1 mg/kg IM associated with: placebo (NaCl 0.9%) 0.05 ml/kg, methadone 0.5 mg/kg or morphine 0.5 mg/kg, depending on the experimental group. Anaesthesia was induced and maintained with isoflurane. Heart (HR) and respiratory (fR) rates, peripheral oxygen saturation (SpO2), mean arterial pressure (MAP), and body temperature were assessed every 10 minutes. Electrocardiographic examination was performed after sedation, in the trans and immediate postoperative period. After procedure, the control group received tramadol 5 mg/kg IV. Postoperative analgesia was assessed using the visual analogue scale (VAS) and Von-Frey filament stimulation responses. All variables were compared between groups by ANOVA or Friedman. Methadone and morphine caused an increase in MAP (p=0.0112) and a decrease in HR (p=0.0001). fR and SpO2 were reduced in the methadone group (p=0.0100). The response to Von-Frey filaments (p=0.6824) and VAS (p=0.7661) were similar between treatments, however, the control group presented a higher proportion of analgesic rescue (33%) compared to morphine (19%) and methadone (12%). Electrocardiographic variables were similar between treatments (p>0.05). In conclusion, preventive treatment with morphine or methadone was effective in controlling trans and postoperative pain in rabbits, and its cardiovascular effects were limited; however, methadone caused marked respiratory depression.-
Descrição: dc.descriptionInstituto de Ciências Agrarias Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM), Unaí, Minas Gerais-
Descrição: dc.descriptionGrupo de Investigación INCA-CES Facultad de Medicina Veterinaria y Zootecnia Universidad CES-
Descrição: dc.descriptionCentro de Investigación el Nus Corporación Colombiana de Investigación Agropecuaria (AGROSAVIA) Corregimiento San José del Nus, Antioquia-
Descrição: dc.descriptionDepartamento de Patobiologia Veterinária e Teriogenologia Faculdade de Ciências Agrárias e Veterinárias Universidade Estadual Paulista «Júlio de Mesquita Filho» (UNESP), Jaboticabal-
Descrição: dc.descriptionDepartamento de Medicina Veterinária União das Faculdades dos Grandes Lagos-
Descrição: dc.descriptionDepartamento de Patobiologia Veterinária e Teriogenologia Faculdade de Ciências Agrárias e Veterinárias Universidade Estadual Paulista «Júlio de Mesquita Filho» (UNESP), Jaboticabal-
Idioma: dc.languagees-
Relação: dc.relationRevista de Investigaciones Veterinarias del Peru-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectanalgesia-
Palavras-chave: dc.subjectanalgesic rescue-
Palavras-chave: dc.subjectmethadone-
Palavras-chave: dc.subjectmorphine-
Palavras-chave: dc.subjectrespiratory depression-
Título: dc.titleEfficacy and safety of morphine and methadone as analgesics in a balanced anaesthetic protocol in rabbits-
Título: dc.titleEficacia y seguridad de morfina y metadona como analgésicos en un protocolo anestésico balanceado en conejos-
Tipo de arquivo: dc.typelivro digital-
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