Effects of cilostazol, a Phosphodiesterase-3 inhibitor, on kidney function and redox imbalance in acute kidney injury caused by Bothrops alternatus venom

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorFederal University of Ceara-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorMarinho, Aline Diogo-
Autor(es): dc.creatorCoelho Jorge, Antônio Rafael-
Autor(es): dc.creatorNogueira Junior, Francisco Assis-
Autor(es): dc.creatorAlison de Moraes Silveira, João-
Autor(es): dc.creatorRocha, Danilo Galvão-
Autor(es): dc.creatorNegreiros Nunes Alves, Ana Paula-
Autor(es): dc.creatorFerreira, Rui Seabra-
Autor(es): dc.creatorBezerra Jorge, Roberta Jeane-
Autor(es): dc.creatorAzul Monteiro, Helena Serra-
Data de aceite: dc.date.accessioned2025-08-21T19:31:07Z-
Data de disponibilização: dc.date.available2025-08-21T19:31:07Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2022-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.toxicon.2022.09.008-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/247790-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/247790-
Descrição: dc.descriptionThe mechanisms of pathogenesis of acute kidney injury (AKI) in snakebites is multifactorial and involves hemodynamic disturbances, with release of free radical causing cytotoxic effects. The phosphodiesterase-3 (PDE3) inhibitor, Cilostazol, has been reported to provide protection against renal oxidative stress. Objective: We evaluated the protective effects of cilostazol against Bothrops alternatus snake venom (BaV)-induced nephrotoxicity. Methods: Wistar rat kidneys (n = 6, 260–300 g) were isolated and perfused with Krebs-Henseleit solution containing 6 g/100 mL of bovine serum albumin. After 30 min, the kidneys were perfused with BaV to a final concentration of 1 and 3 μg/mL, and subsequently evaluated for perfusion pressure (PP), renal vascular resistance (RVR), urinary flow (UF), glomerular filtration rate (GFR), and percentage of electrolyte tubular sodium and chloride transport (%TNa+, %TCl–). Oxidative stress and renal histological analyses were performed. Results: BaV caused a reduction in all the evaluated renal parameters (PP, RVR, GFR, UF, %TNa+, and %TCl–). Although only the effects on PP and UF were reversed with cilostazol treatment, the decrease in the malondialdehyde levels, without changes in glutathione levels, further reduced the venom-induced renal tissue changes. Conclusion: Our data suggest that PDE3 is involved in BaV-induced nephrotoxicity, as cilostazol administration significantly ameliorated these effects.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionDepartment of Physiology and Pharmacology School of Medicine Federal University of Ceara, Coronel Nunes de Melo St., 1127, CE-
Descrição: dc.descriptionDrug Research and Development Center (NPDM) Federal University of Ceara, Coronel Nunes de Melo St., 1000, CE-
Descrição: dc.descriptionDepartment of Dental Clinic School of Pharmacy Dentistry and Nursing Federal University of Ceara, Fortaleza, Monsenhor Furtado St.-
Descrição: dc.descriptionCenter for the Study of Venoms and Venomous Animals Fazenda Experimental Lageado São Paulo State University, José Barbosa de Barros St., 1780, SP-
Descrição: dc.descriptionCenter for the Study of Venoms and Venomous Animals Fazenda Experimental Lageado São Paulo State University, José Barbosa de Barros St., 1780, SP-
Idioma: dc.languageen-
Relação: dc.relationToxicon-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBothrops alternatus-
Palavras-chave: dc.subjectKidney injury-
Palavras-chave: dc.subjectKidney perfusion-
Palavras-chave: dc.subjectPhosphodiesterase-3 inhibitor-
Palavras-chave: dc.subjectSnake envenomation-
Título: dc.titleEffects of cilostazol, a Phosphodiesterase-3 inhibitor, on kidney function and redox imbalance in acute kidney injury caused by Bothrops alternatus venom-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.