Mantle cell lymphoma involving the oral and maxillofacial region: a study of 20 cases

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Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversidade Federal de Minas Gerais (UFMG)-
Autor(es): dc.contributorFederal University of Rio Grande do Sul-
Autor(es): dc.contributorCentro Clínico de Cabeza y Cuello/Hospital Herrera Llerandi-
Autor(es): dc.contributorRio de Janeiro State University-
Autor(es): dc.contributorUniversity of Pretoria-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorCentro Universitário Católico Unisalesiano Auxilium-
Autor(es): dc.contributorUniversidade Federal do Pará (UFPA)-
Autor(es): dc.contributorGetúlio Sales Diagnósticos-
Autor(es): dc.contributorPrivate practice-
Autor(es): dc.creatorCarvalho, Marcus Vinícius Ribeiro-
Autor(es): dc.creatorRodrigues-Fernandes, Carla Isabelly-
Autor(es): dc.creatorde Cáceres, Cinthia Veronica Bardález López-
Autor(es): dc.creatorMesquita, Ricardo Alves-
Autor(es): dc.creatorMartins, Manoela Domingues-
Autor(es): dc.creatorRomán Tager, Elena María José-
Autor(es): dc.creatorCarlos, Roman-
Autor(es): dc.creatorPires, Fábio Ramôa-
Autor(es): dc.creatorRobinson, Liam-
Autor(es): dc.creatorvan Heerden, Willie F.P.-
Autor(es): dc.creatorValente, Vitor Bonetti-
Autor(es): dc.creatorXavier-Júnior, José Cândido Caldeira-
Autor(es): dc.creatorBernabé, Daniel Galera-
Autor(es): dc.creatorPontes, Hélder Antônio Rebelo-
Autor(es): dc.creatorSoares, Ciro Dantas-
Autor(es): dc.creatorda Costa, Mauro Henrique Melo-
Autor(es): dc.creatorVargas, Pablo Agustin-
Autor(es): dc.creatorFonseca, Felipe Paiva-
Data de aceite: dc.date.accessioned2025-08-21T22:03:45Z-
Data de disponibilização: dc.date.available2025-08-21T22:03:45Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2022-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.oooo.2022.08.018-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/247699-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/247699-
Descrição: dc.descriptionObjective: To investigate the clinicopathologic features of mantle cell lymphoma (MCL) involving the oral and maxillofacial region. Methods: The MCL cases were retrieved from the pathosis database of 6 pathology laboratories. Original hematoxylin and eosin slides and immunohistochemical reactions were reviewed for confirmation of the initial diagnosis. Clinical data of the cases were obtained from the patients’ pathosis and/or medical charts. Results: Twenty cases were included in the study, showing a male predominance and a mean age of 66 years. The oral cavity (12 cases) and the oropharynx (5 cases) were the most commonly involved subsites. Most cases presented as asymptomatic swellings, with 2 cases showing bilateral involvement of the palate. The classic histologic variant predominated (12/20 cases). All cases expressed CD20 with nuclear cyclin D1 positivity. SOX11 was seen in 9/13 cases, CD5 in 6/16 cases, Bcl2 in 16/19 cases, CD10 in 2/20 cases, and Bcl6 in 4/16 cases. Ki67 showed a mean proliferation index of 40.6%. The Epstein-Barr virus (EBV) was negative in all cases investigated. Follow-up data was available for 7 patients, with 5 currently alive and 2 deceased. Conclusion: Mantle cell lymphoma, albeit rare, may manifest in the oral and maxillofacial region. Its histologic heterogeneity demands a high degree of diagnostic skill from pathologists.-
Descrição: dc.descriptionDepartment of Oral Diagnosis Piracicaba Dental School University of Campinas-
Descrição: dc.descriptionDepartment of Oral Surgery and Pathology School of Dentistry Universidade Federal de Minas Gerais-
Descrição: dc.descriptionDepartment of Oral Pathology School of Dentistry Federal University of Rio Grande do Sul-
Descrição: dc.descriptionPathology Section Centro Clínico de Cabeza y Cuello/Hospital Herrera Llerandi-
Descrição: dc.descriptionOral Pathology Dental School Rio de Janeiro State University-
Descrição: dc.descriptionDepartment of Oral Pathology and Oral Biology School of Dentistry Faculty of Health Sciences University of Pretoria-
Descrição: dc.descriptionOral Oncology Center São Paulo State University (UNESP) School of Dentistry-
Descrição: dc.descriptionPathology Institute of Araçatuba and School of Medicine Centro Universitário Católico Unisalesiano Auxilium-
Descrição: dc.descriptionOral Pathology Service João de Barros Barreto University Hospital Federal University of Pará-
Descrição: dc.descriptionGetúlio Sales Diagnósticos-
Descrição: dc.descriptionPrivate practice-
Descrição: dc.descriptionOral Oncology Center São Paulo State University (UNESP) School of Dentistry-
Formato: dc.format101-109-
Idioma: dc.languageen-
Relação: dc.relationOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology-
???dc.source???: dc.sourceScopus-
Título: dc.titleMantle cell lymphoma involving the oral and maxillofacial region: a study of 20 cases-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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