Effects of high-fat diet-induced diabetes on autophagy in the murine liver: A systematic review and meta-analysis

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorFederal University of Mato Grosso (UFMT)-
Autor(es): dc.creatorda Cruz, Larissa Lopes-
Autor(es): dc.creatorVesentini, Giovana-
Autor(es): dc.creatorSinzato, Yuri Karen-
Autor(es): dc.creatorVillaverde, Ana Izabel Silva Balbin-
Autor(es): dc.creatorVolpato, Gustavo Tadeu-
Autor(es): dc.creatorDamasceno, Débora Cristina-
Data de aceite: dc.date.accessioned2025-08-21T16:06:19Z-
Data de disponibilização: dc.date.available2025-08-21T16:06:19Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2022-11-14-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.lfs.2022.121012-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/247689-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/247689-
Descrição: dc.descriptionAims: We conducted a meta-analysis to investigate whether diabetes induced by a high-fat diet (HFD) has the potential to alter the process of autophagy in the murine liver. Methods: A systematic literature search was performed with electronic databases (PubMed, EMBASE, Web of Science). Study design, population, intervention, outcome, and risk of bias were analyzed. Given the availability of studies, a quantitative meta-analysis including 23 studies was performed. Key findings: The search found 5754 articles, with 48 matching the eligibility criteria, comprising of 1033 animals. The meta-analysis showed that diabetic murines fed with HFD presented an absence of p62 degradation (SMD 4.63, 95 % CI 2.02 to 7.24, p = 0.0005; I2 = 77 %), higher expression of p-mTOR/mTOR (SMD 5.20, 95 % CI 1.00 to 9.39, p = 0.01; I2 = 78 %), and a decreased p-AMPK/AMPK ratio (SMD -2.02, 95 % CI -3.96 to −0.09, p = 0.04; I2 = 85 %) when compared to nondiabetic murines. When associated with streptozotocin, the animals presented decreased ATG-7 and LC3-II. The meta-regression results showed a decrease in autophagy responses due to increased glycemic levels, fat content, and long-term exposure to HFD, and advanced animal age. The common and species-specific protein responses were also consistent with the inhibition of autophagy. Significance: The normal process of autophagy mechanisms in the liver is less competent after HFD consumption. The destabilization of (auto)phagolysosomes contributes to the perpetuation of diabetes, metabolic dysfunction-associated fatty liver disease, and cell death.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionLaboratory of Experimental Research on Gynecology and Obstetrics Postgraduate Course on Tocogynecology Botucatu Medical School São Paulo State University (Unesp), São Paulo State-
Descrição: dc.descriptionLaboratory of System Physiology and Reproductive Toxicology Institute of Biological and Health Sciences Federal University of Mato Grosso (UFMT), Mato Grosso State-
Descrição: dc.descriptionLaboratory of Experimental Research on Gynecology and Obstetrics Postgraduate Course on Tocogynecology Botucatu Medical School São Paulo State University (Unesp), São Paulo State-
Descrição: dc.descriptionCAPES: 001-
Descrição: dc.descriptionFAPESP: 2016/25207-5-
Idioma: dc.languageen-
Relação: dc.relationLife Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAnimal models-
Palavras-chave: dc.subjectHepatocyte-
Palavras-chave: dc.subjectHigh-fat diet-
Palavras-chave: dc.subjectHyperglycemia-
Palavras-chave: dc.subjectMacroautophagy-
Título: dc.titleEffects of high-fat diet-induced diabetes on autophagy in the murine liver: A systematic review and meta-analysis-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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