Blood plasma proteome alteration after local tissue damage induced by Bothrops erythromelas snake venom in mice

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorParaíba State University (UEPB)-
Autor(es): dc.contributorFederal University of Ceará (UFC)-
Autor(es): dc.contributorFederal University of ABC-
Autor(es): dc.creatorCavalcante, Joeliton S.-
Autor(es): dc.creatorBorges da Silva, Weslley Ruan G.-
Autor(es): dc.creatorde Oliveira, Laudicéia Alves-
Autor(es): dc.creatorBrito, Ingrid Mayara C.-
Autor(es): dc.creatorMuller, Kevin S.-
Autor(es): dc.creatorJ. Vidal, Ivynna Suellen-
Autor(es): dc.creatordos Santos, Lucilene Delazari-
Autor(es): dc.creatorJorge, Roberta Jeane Bezerra-
Autor(es): dc.creatorAlmeida, Cayo-
Autor(es): dc.creatorde Lima Bicho, Carla-
Data de aceite: dc.date.accessioned2025-08-21T17:47:27Z-
Data de disponibilização: dc.date.available2025-08-21T17:47:27Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2022-10-29-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.jprot.2022.104742-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/247686-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/247686-
Descrição: dc.descriptionSnakes of the genus Bothrops are responsible the most snakebites in the Brazil, causing a diverse and complex pathophysiological condition. Bothrops erythromelas is the main specie of medical relevance found in the Caatinga from the Brazilian Northeast region. The pathophysiological effects involving B. erythromelas snakebite as well as the organism reaction in response to this envenomation are not so explored. Thus, edema was induced in mice paws using 2.5 μg or 5.0 μg of B. erythromelas venom, and the percentage of edema was measured. Plasma was collected 30 minutes after the envenomation-induced in mice and analyzed by mass spectrometry. It was identified a total of 112 common plasma proteins differentially abundant among experimental groups, which are involved with the complement system and coagulation cascades, oxidative stress, neutrophil degranulation, platelets degranulation and inflammatory response. Apolipoprotein A1 (Apoa), serum amyloid protein A-4 (Saa4), adiponectin (Adipoq) showed up-regulated in mice plasma after injection of venom, while fibulin (Fbln1), factor XII (F12) and vitamin K-dependent protein Z (Proz) showed down-regulated. The results indicate a protein pattern of thrombo-inflammation to the B. erythromelas snakebite, evidencing potential biomarkers for monitoring this snakebite, new therapeutic targets and its correlations with the degree of envenomation once showed modulations in the abundance among the different groups according to the amount of venom injected into the mice.-
Descrição: dc.descriptionGraduate Program in Tropical Diseases Botucatu Medical School (FMB) São Paulo University (UNESP - Univ Estadual Paulista), São Paulo-
Descrição: dc.descriptionDepartment of Biology Center of Biological and Health Sciences Paraíba State University (UEPB), Paraíba-
Descrição: dc.descriptionInstitute of Biosciences São Paulo University (UNESP - Univ Estadual Paulista), São Paulo-
Descrição: dc.descriptionGraduate Program in Translational Medicine Drug Research and Development Center Federal University of Ceará (UFC), Ceará-
Descrição: dc.descriptionBiotechnology Institute (IBTEC) São Paulo University (UNESP - Univ Estadual Paulista), São Paulo-
Descrição: dc.descriptionDrug Research and Development Center Federal University of Ceará (UFC), Ceará-
Descrição: dc.descriptionDepartment of Physiology and Pharmacology School of Medicine Federal University of Ceará (UFC), Ceará-
Descrição: dc.descriptionCenter of Mathematics Computing Sciences and Cognition Federal University of ABC, SP-
Descrição: dc.descriptionGraduate Program in Tropical Diseases Botucatu Medical School (FMB) São Paulo University (UNESP - Univ Estadual Paulista), São Paulo-
Descrição: dc.descriptionInstitute of Biosciences São Paulo University (UNESP - Univ Estadual Paulista), São Paulo-
Descrição: dc.descriptionBiotechnology Institute (IBTEC) São Paulo University (UNESP - Univ Estadual Paulista), São Paulo-
Idioma: dc.languageen-
Relação: dc.relationJournal of Proteomics-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectEdema-
Palavras-chave: dc.subjectInflammation-
Palavras-chave: dc.subjectMass spectrometry-
Palavras-chave: dc.subjectSnake venom-
Palavras-chave: dc.subjectThromboinflammation-
Título: dc.titleBlood plasma proteome alteration after local tissue damage induced by Bothrops erythromelas snake venom in mice-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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