Photodynamic therapy for treating infected skin wounds: A systematic review and meta-analysis from randomized clinical trials

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUNAERP - Department of Dentistry-
Autor(es): dc.creatorde Oliveira, Analú Barros-
Autor(es): dc.creatorFerrisse, Túlio Morandin-
Autor(es): dc.creatorFontana, Carla Raquel-
Autor(es): dc.creatorBasso, Fernanda Gonçalves-
Autor(es): dc.creatorBrighenti, Fernanda Lourenção-
Data de aceite: dc.date.accessioned2025-08-21T23:11:05Z-
Data de disponibilização: dc.date.available2025-08-21T23:11:05Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2022-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.pdpdt.2022.103118-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/247674-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/247674-
Descrição: dc.descriptionBackground: Infected skin wounds represent a public health problem that effects 20 million people worldwide. Photodynamic therapy (PDT) is a treatment option with excellent results against several infections. Objective: This study aimed to perform a systematic review and meta-analysis on PDT efficacy for treating infected wounds based on randomized clinical trials (RCTs). Methods: PubMed, Scopus, Web of Science, SciELO, and the Cochrane library were searched. The Delphi List criteria and the Revised Cochrane risk-of-bias (Rob 2) were used for evaluating the quality of clinical trials. Meta-analyses were performed with the random-effect model. The odds ratio was the effect measure for binary outcomes, while the standard mean difference was used for continuous outcomes. The trim-and-fill method was used to detect small-study effects. The quality of evidence was verified for each outcome. Results: Only four out of 573 articles were selected for the qualitative and quantitative analyses. The most frequent cause of infected wounds was impaired venous circulation (75%). All studies used red LED light. PDT reduced healing time and improved the healing process and wound oxygenation. Patients treated with PDT showed 15% to 17% (p = 0.0003/ I2=0%) lower microbial cell viability in the wound and a significantly smaller wound size (0.72 cm2/p = 0.0187/I2=0%) than patients treated with placebo or red-light exposure. There was a high level of evidence for each meta-analysis outcome. Conclusion: PDT can be an excellent alternative treatment for infected skin wounds, though larger trials are needed.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Dentistry - Department of Morphology Genetics Orthodontics and Pediatric Dentistry, São Paulo-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Dentistry – Department of Dental Materials and Prosthodontics, São Paulo-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Pharmaceutical Sciences - Department of Clinical Analysis, São Paulo-
Descrição: dc.descriptionUniversidade de Ribeirão Preto UNAERP - Department of Dentistry, SP-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Dentistry - Department of Morphology Genetics Orthodontics and Pediatric Dentistry, São Paulo-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Dentistry – Department of Dental Materials and Prosthodontics, São Paulo-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Pharmaceutical Sciences - Department of Clinical Analysis, São Paulo-
Descrição: dc.descriptionCAPES: 001-
Descrição: dc.descriptionFAPESP: 020/07110-0-
Descrição: dc.descriptionFAPESP: 2013/07276-1-
Descrição: dc.descriptionFAPESP: 2018/18440-0-
Descrição: dc.descriptionFAPESP: 2018/23015-7-
Descrição: dc.descriptionFAPESP: 2019/08375-0-
Descrição: dc.descriptionFAPESP: 2021/01191-0-
Idioma: dc.languageen-
Relação: dc.relationPhotodiagnosis and Photodynamic Therapy-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectInfected skin wounds-
Palavras-chave: dc.subjectInfection-
Palavras-chave: dc.subjectMeta-analysis-
Palavras-chave: dc.subjectPhotodynamic therapy-
Palavras-chave: dc.subjectSystematic review-
Título: dc.titlePhotodynamic therapy for treating infected skin wounds: A systematic review and meta-analysis from randomized clinical trials-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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