Curcumin-Loaded Mesoporous Silica Nanoparticles Dispersed in Thermo-Responsive Hydrogel as Potential Alzheimer Disease Therapy

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Federal da Bahia (UFBA)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorRibeiro, Tais de Cassia-
Autor(es): dc.creatorSábio, Rafael Miguel-
Autor(es): dc.creatorLuiz, Marcela Tavares-
Autor(es): dc.creatorde Souza, Lucas Canto-
Autor(es): dc.creatorFonseca-Santos, Bruno-
Autor(es): dc.creatorCides da Silva, Luis Carlos-
Autor(es): dc.creatorFantini, Márcia Carvalho de Abreu-
Autor(es): dc.creatorPlaneta, Cleopatra da Silva-
Autor(es): dc.creatorChorilli, Marlus-
Data de aceite: dc.date.accessioned2025-08-21T19:29:16Z-
Data de disponibilização: dc.date.available2025-08-21T19:29:16Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2022-09-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/pharmaceutics14091976-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/247660-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/247660-
Descrição: dc.descriptionAlzheimer’s disease (AD) is a neurodegenerative disorder characterized by cognitive and behavioral impairment. Curcumin-loaded mesoporous silica nanoparticles (MSN-CCM) can overcome the drawbacks related to the free curcumin (CCM) clinical application, such as water insolubility and low bioavailability, besides acting over the main causes associated to AD. A thermo-responsive hydrogel is an interesting approach for facilitating the administration of the nanosystem via a nasal route, as well as for overcoming mucociliary clearance mechanisms. In light of this, MSN-CCM were dispersed in the hydrogel and evaluated through in vitro and in vivo assays. The MSNs and MSN-CCM were successfully characterized by physicochemical analysis and a high value of the CCM encapsulation efficiency (EE%, 87.70 ± 0.05) was achieved. The designed thermo-responsive hydrogel (HG) was characterized by rheology, texture profile analysis, and ex vivo mucoadhesion, showing excellent mechanical and mucoadhesive properties. Ex vivo permeation studies of MSN-CCM and HG@MSN-CCM showed high permeation values (12.46 ± 1.08 and 28.40 ± 1.88 μg cm−2 of CCM, respectively) in porcine nasal mucosa. In vivo studies performed in a streptozotocin-induced AD model confirmed that HG@MSN-CCM reverted the cognitive deficit in mice, acting as a potential formulation in the treatment of AD.-
Descrição: dc.descriptionDepartment of Drugs and Medicines School of Pharmaceutical Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Biotechnology Health Sciences Institute Federal University of Bahia (UFBA)-
Descrição: dc.descriptionInstitute of Physics University of São Paulo (IF-USP)-
Descrição: dc.descriptionDepartment of Drugs and Medicines School of Pharmaceutical Sciences São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationPharmaceutics-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectbrain disorders-
Palavras-chave: dc.subjectcurcuminoids-
Palavras-chave: dc.subjectdrug delivery systems-
Palavras-chave: dc.subjectmesoporous silica nanoparticles-
Palavras-chave: dc.subjectneurodegenerative disorder-
Título: dc.titleCurcumin-Loaded Mesoporous Silica Nanoparticles Dispersed in Thermo-Responsive Hydrogel as Potential Alzheimer Disease Therapy-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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