The Effectiveness of Therapeutic Vaccines for the Treatment of Cervical Intraepithelial Neoplasia 3: A Systematic Review and Meta-Analysis

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Autor(es): dc.contributorUniversity of Beira Interior-
Autor(es): dc.contributorUniversidade da Beira Interior-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorIRCCS Regina Elena National Cancer Institute-
Autor(es): dc.creatorVentura, Cathy-
Autor(es): dc.creatorLuís, Ângelo-
Autor(es): dc.creatorSoares, Christiane P.-
Autor(es): dc.creatorVenuti, Aldo-
Autor(es): dc.creatorPaolini, Francesca-
Autor(es): dc.creatorPereira, Luísa-
Autor(es): dc.creatorSousa, Ângela-
Data de aceite: dc.date.accessioned2025-08-21T20:30:47Z-
Data de disponibilização: dc.date.available2025-08-21T20:30:47Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2022-09-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/vaccines10091560-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/247659-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/247659-
Descrição: dc.descriptionCervical cancer (CC) is a disease that affects many women worldwide, especially in low-income countries. The human papilloma virus (HPV) is the main causative agent of this disease, with the E6 and E7 oncoproteins being responsible for the development and maintenance of transformed status. In addition, HPV is also responsible for the appearance of cervical intraepithelial neoplasia (CIN), a pre-neoplastic condition burdened by very high costs for its screening and therapy. So far, only prophylactic vaccines have been approved by regulatory agencies as a means of CC prevention. However, these vaccines cannot treat HPV-positive women. A search was conducted in several databases (PubMed, Scopus, Web of Science, and ClinicalTrials.gov) to systematically identify clinical trials involving therapeutic vaccines against CIN 3. Histopathological regression data, immunological parameters, safety, DNA clearance, and vaccine efficacy were considered from each selected study, and from the 102 articles found, 8 were selected based on the defined inclusion criteria. Histopathological regression from CIN 3 to CIN < 1 was 22.1% (95% CI: 0.627–0.967; p-value = 0.024), showing a vaccine efficacy of 23.6% (95% CI; 0.666–0.876; p-value < 0.001). DNA clearance was assessed, and the risk of persistent HPV DNA was 23.2% (95% CI: 0.667–0.885; p-value < 0.001). Regarding immunological parameters, immune responses by specific T-HPV cells were more likely in vaccinated women (95% CI: 1.245–9.162; p-value = 0.017). In short, these studies favored the vaccine group over the placebo group. This work indicated that therapeutic vaccines are efficient in the treatment of CIN 3, even after accounting for publication bias.-
Descrição: dc.descriptionCICS-UBI–Health Science Research Centre University of Beira Interior, Av. Infante D. Henrique-
Descrição: dc.descriptionGrupo de Revisões Sistemáticas (GRUBI) Faculdade de Ciências da Saúde Universidade da Beira Interior-
Descrição: dc.descriptionDepartment of Clinical Analysis School of Pharmaceutical Sciences São Paulo State University (UNESP), Campus Ville, SP-
Descrição: dc.descriptionHPV-UNIT-UOSD Tumor Immunology and Immunotherapy IRCCS Regina Elena National Cancer Institute-
Descrição: dc.descriptionCMA-UBI-Centro de Matemática e Aplicações Universidade da Beira Interior-
Descrição: dc.descriptionCloud Computing Competence Centre University of Beira Interior-
Descrição: dc.descriptionDepartment of Clinical Analysis School of Pharmaceutical Sciences São Paulo State University (UNESP), Campus Ville, SP-
Idioma: dc.languageen-
Relação: dc.relationVaccines-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectcervical cancer-
Palavras-chave: dc.subjectclinical trials-
Palavras-chave: dc.subjectmeta-analysis-
Palavras-chave: dc.subjectsystematic review-
Palavras-chave: dc.subjecttherapeutics vaccines-
Título: dc.titleThe Effectiveness of Therapeutic Vaccines for the Treatment of Cervical Intraepithelial Neoplasia 3: A Systematic Review and Meta-Analysis-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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