Novel Ru(II)-bipyridine/phenanthroline-lapachol complexes as potential anti-cancer agents

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUNIARA – University of Araraquara-
Autor(es): dc.contributorUniversidade Federal de São Carlos (UFSCar)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Federal do Rio de Janeiro (UFRJ)-
Autor(es): dc.creatorDe Grandis, Rone Aparecido-
Autor(es): dc.creatorCosta, Analu Rocha-
Autor(es): dc.creatorMoraes, Carlos André Ferreira-
Autor(es): dc.creatorSampaio, Natália Zaneti-
Autor(es): dc.creatorCerqueira, Igor Henrique-
Autor(es): dc.creatorMarques, Wellington Garcia-
Autor(es): dc.creatorGuedes, Adriana Pereira Mundin-
Autor(es): dc.creatorde Araujo-Neto, João Honorato-
Autor(es): dc.creatorPavan, Fernando Rogério-
Autor(es): dc.creatorDemidoff, Felipe Cerqueira-
Autor(es): dc.creatorNetto, Chaquip Daher-
Autor(es): dc.creatorBatista, Alzir Azevedo-
Autor(es): dc.creatorResende, Flávia Aparecida-
Data de aceite: dc.date.accessioned2025-08-21T16:48:47Z-
Data de disponibilização: dc.date.available2025-08-21T16:48:47Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2022-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.jinorgbio.2022.112005-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/247650-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/247650-
Descrição: dc.descriptionFor the first time, we herein report on the syntheses of two new Ru(II)/bipyridine/phenanthroline complexes containing lapachol as ligand: complex (1), [Ru (bipy)2(Lap)]PF6 and complex (2), [Ru(Lap)(phen)2]PF6, where bipy = 2,2′-bipyridine and ph en = 1,10-phenanthroline; Lap = lapachol (2-hydroxy-3-(3-methylbut-2-en-1- yl)naphthalene-1,4-dione). The complexes were synthesized and characterized by elemental analyses, molar conductivity, mass spectrometry, ultraviolet-visible and infrared spectroscopies, nuclear magnetic resonance (1H, 13C), and single crystal X-ray diffraction, for complex (2). In addition, in vitro cytotoxicity was tested against six cancer cells: A549 (lung carcinoma); DU-145 (human prostate carcinoma); HepG2 (human hepatocellular carcinoma), PC-3 (human prostate adenocarcinoma); MDA-MB-231 (human breast adenocarcinoma); Caco-2 (human colorectal adenocarcinoma), and against two non-cancer cells, FGH (human gingival normal fibroblasts) and PNT-2 (prostate epithelial cells). Complex (1) was slightly more toxic and selective than complex (2) for all cell lines, except against the A549 cells, where (2) was more potent than complex (1). The complexes induced an increase in the reactive oxygen species, and the co-treatment with N-acetyl-L-cysteine remarkably suppressed the ROS generation and prevented the reduction of cell viability, suggesting that the cytotoxicity of the complexes is related to the ROS-mediated pathway. Further studies indicated that the complexes may bind to DNA via minor groove interaction. Our studies also revealed that free Lap induces gene mutations in Salmonella Typhimurium, nevertheless, the complexes demonstrated the absence of genotoxicity by the Ames test. The present study provides a relevant contribution to understanding the anti-cancer potential and genetic toxicological events of new ruthenium complexes containing the lapachol molecule as a ligand.-
Descrição: dc.descriptionUNIARA – University of Araraquara Department of Biological Sciences and Health, São Paulo-
Descrição: dc.descriptionUFSCar - Federal University of São Carlos Department of Chemistry, São Paulo-
Descrição: dc.descriptionUNESP - São Paulo State University Department of Biological Sciences School of Pharmaceutical Sciences, São Paulo-
Descrição: dc.descriptionUFRJ - Federal University of Rio de Janeiro Institute of Chemistry, Rio de Janeiro-
Descrição: dc.descriptionUNESP - São Paulo State University Department of Biological Sciences School of Pharmaceutical Sciences, São Paulo-
Idioma: dc.languageen-
Relação: dc.relationJournal of Inorganic Biochemistry-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCytotoxicity-
Palavras-chave: dc.subjectGenotoxicity-
Palavras-chave: dc.subjectLapachol-
Palavras-chave: dc.subjectReactive oxygen species-
Palavras-chave: dc.subjectRuthenium complexes-
Título: dc.titleNovel Ru(II)-bipyridine/phenanthroline-lapachol complexes as potential anti-cancer agents-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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