Experimental Bothrops atrox Envenomation: Blood Plasma Proteome Effects after Local Tissue Damage and Perspectives on Thromboinflammation

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorFederal University of ABC-
Autor(es): dc.contributorFederal University of Ceará-
Autor(es): dc.contributorFederal University of Ceará (UFC)-
Autor(es): dc.creatorCavalcante, Joeliton S.-
Autor(es): dc.creatorBrito, Ingrid Mayara da Cunha-
Autor(es): dc.creatorDe Oliveira, Laudicéia Alves-
Autor(es): dc.creatorDe Barros, Luciana Curtolo-
Autor(es): dc.creatorAlmeida, Cayo-
Autor(es): dc.creatorRossini, Bruno Cesar-
Autor(es): dc.creatorSousa, Duaran Lopes-
Autor(es): dc.creatorAlves, Renata Sousa-
Autor(es): dc.creatorJorge, Roberta Jeane Bezerra-
Autor(es): dc.creatorSantos, Lucilene Delazari dos-
Data de aceite: dc.date.accessioned2025-08-21T19:09:47Z-
Data de disponibilização: dc.date.available2025-08-21T19:09:47Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2022-09-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/toxins14090613-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/247641-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/247641-
Descrição: dc.descriptionThe clinical manifestations of Bothrops atrox envenoming involve local and systemic changes, among which edema requires substantial attention due to its ability to progress to compartmental syndromes and sometimes cause tissue loss and amputations. However, the impact of edema on the poisoned body’s system has not been explored. Thus, the present study aimed to explore the systemic pathological and inflammatory events that are altered by intraplantar injection of B. atrox venom in a mouse model through hematologic, lipidic, and shotgun proteomics analysis. Plasma samples collected showed a greater abundance of proteins related to complement, coagulation, lipid system, platelet and neutrophil degranulation, and pathways related to cell death and ischemic tolerance. Interestingly, some proteins, in particular, Prdx2 (peroxiredoxin 2), Hba (hemoglobin subunit alpha), and F9 (Factor IX), increased according to the amount of venom injected. Our findings support that B. atrox venom activates multiple blood systems that are involved in thromboinflammation, an observation that may have implications for the pathophysiological progression of envenomations. Furthermore, we report for the first time a potential role of Prdx2, Hba, and F9 as potential markers of the severity of edema/inflammation in mice caused by B. atrox.-
Descrição: dc.descriptionGraduate Program in Tropical Diseases Botucatu Medical School (FMB) São Paulo State University (UNESP)-
Descrição: dc.descriptionCenter for the Study of Venoms and Venomous Animals (CEVAP) São Paulo State University (UNESP)-
Descrição: dc.descriptionCenter of Mathematics Computing Sciences and Cognition Federal University of ABC-
Descrição: dc.descriptionBiotechnology Institute (IBTEC) São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Chemical and Biological Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Clinical and Toxicological Analysis Federal University of Ceará-
Descrição: dc.descriptionDrug Research and Development Center Federal University of Ceará (UFC)-
Descrição: dc.descriptionDepartment of Physiology and Pharmacology School of Medicine Federal University of Ceará (UFC)-
Descrição: dc.descriptionGraduate Program in Research and Development Medical Biotechnology Botucatu Medical School (FMB) São Paulo State University (UNESP)-
Descrição: dc.descriptionGraduate Program in Tropical Diseases Botucatu Medical School (FMB) São Paulo State University (UNESP)-
Descrição: dc.descriptionCenter for the Study of Venoms and Venomous Animals (CEVAP) São Paulo State University (UNESP)-
Descrição: dc.descriptionBiotechnology Institute (IBTEC) São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Chemical and Biological Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionGraduate Program in Research and Development Medical Biotechnology Botucatu Medical School (FMB) São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationToxins-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBothrops atrox-
Palavras-chave: dc.subjectedema-
Palavras-chave: dc.subjectinflammation-
Palavras-chave: dc.subjectproteomic analysis-
Palavras-chave: dc.subjectsnake venom-
Palavras-chave: dc.subjectthromboinflammation-
Título: dc.titleExperimental Bothrops atrox Envenomation: Blood Plasma Proteome Effects after Local Tissue Damage and Perspectives on Thromboinflammation-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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