C-reactive protein concentrations are higher in dogs with stage IV chronic kidney disease treated with intermittent hemodialysis

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorPet Care Veterinary Hospital Pacaembu Unit-
Autor(es): dc.creatorPicelli de Azevedo, Maria Gabriela-
Autor(es): dc.creatorSalgueiro Geraldes, Silvano-
Autor(es): dc.creatorBilbau Sant'Anna, Paula-
Autor(es): dc.creatorPoloni Batista, Beatriz-
Autor(es): dc.creatorRodrigues Maia, Suellen-
Autor(es): dc.creatorSilveira de Moraes, Reiner-
Autor(es): dc.creatorMoreira Dos Santos Schmidt, Elizabeth-
Autor(es): dc.creatorFerreira de Souza, Fabiana-
Autor(es): dc.creatorMelchert, Alessandra-
Autor(es): dc.creatorPinheiro Ferreira, João Carlos-
Autor(es): dc.creatorRezende Dadalto, Carmel-
Autor(es): dc.creatorMogollón García, Henry David-
Autor(es): dc.creatorChalfun Guimarães-Okamoto, Priscylla Tatiana-
Data de aceite: dc.date.accessioned2025-08-21T18:38:26Z-
Data de disponibilização: dc.date.available2025-08-21T18:38:26Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2021-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1371/journal.pone.0274510-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/247638-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/247638-
Descrição: dc.descriptionIn chronic kidney disease dogs, the inflammatory process increases C-reactive protein concentrations. This study aimed to determine C-reactive protein serum concentrations in stage IV chronic kidney disease dogs treated with intermittent hemodialysis. A prospective cohort study was conducted with 23 dogs allocated into three groups: control group (CG, n = 7), intermittent hemodialysis group (IHG, n = 8) and clinical treatment group (CTG, n = 8), both comprised of stage IV chronic kidney disease dogs. One blood sample from CG (initial evaluation) and two samples from IHG and CTG (first- and last-moment) were obtained to determine C-reactive protein concentration, total leukocytes, platelets, erythrocytes, total plasma protein, serum albumin, urea, creatinine, and phosphorus. C-reactive protein was higher in IHG compared to CG in the first- and last-moments (p <0.001) and compared to CTG in the first-moment (p = 0.0406). C-reactive protein presented moderate positive correlation with leukocytes (r = 0.5479; p = 0.01), and moderate negative correlation with albumin (r = - 0.5974; p = 0.006) and red blood cells (r = - 0.5878, p = 0.01). A high correlation coefficient was observed in the tests' evaluation (CI = 0.59-0.78; r = 0.70; P<0.0001). In conclusion, both assays used in this study to measure C-reactive protein have provided safe and reliable quantification of the results. Additionally, despite IHG dogs presented an active inflammatory profile, intermittent hemodialysis has proven to be beneficial, leading to a clinical improvement in life quality of patients, and thus being recommended for stage IV CKD dogs when performed by trained professionals.-
Descrição: dc.descriptionDepartment of Veterinary Clinics School of Veterinary Medicine and Animal Science São Paulo State University (UNESP)-
Descrição: dc.descriptionPet Care Veterinary Hospital Pacaembu Unit-
Descrição: dc.descriptionDepartment of Veterinary Surgery and Animal Reproduction School of Veterinary Medicine and Animal Science São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Veterinary Clinics School of Veterinary Medicine and Animal Science São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Veterinary Surgery and Animal Reproduction School of Veterinary Medicine and Animal Science São Paulo State University (UNESP)-
Formato: dc.formate0274510-
Idioma: dc.languageen-
Relação: dc.relationPloS one-
???dc.source???: dc.sourceScopus-
Título: dc.titleC-reactive protein concentrations are higher in dogs with stage IV chronic kidney disease treated with intermittent hemodialysis-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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