Sonchus oleraceus L. Promotes Gastroprotection in Rodents via Antioxidant, Anti-Inflammatory, and Antisecretory Activities

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorCommunity University of Chapeco Region-
Autor(es): dc.contributorCommunity University of Chapecó Region-
Autor(es): dc.contributorUniversity of Vale Do Itajaí-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorAlto Vale Do Rio Do Peixe University-
Autor(es): dc.creatorVecchia, Cristian A. D.-
Autor(es): dc.creatorLocateli, Gelvani-
Autor(es): dc.creatorSerpa, Patricia Z.-
Autor(es): dc.creatorBianchin Gomes, Denise-
Autor(es): dc.creatorErnetti, Jackeline-
Autor(es): dc.creatorMiorando, Daniela-
Autor(es): dc.creatorZanatta, Maria Eduarda D. C.-
Autor(es): dc.creatorKaio Silva Nunes, Ruan-
Autor(es): dc.creatorWildner, Silvana M.-
Autor(es): dc.creatorGutiérrez, Max V.-
Autor(es): dc.creatorVilegas, Wagner-
Autor(es): dc.creatorSomensi, Lincon B.-
Autor(es): dc.creatorSilva, Luisa M.-
Autor(es): dc.creatorRoman, Walter A.-
Data de aceite: dc.date.accessioned2025-08-21T23:14:02Z-
Data de disponibilização: dc.date.available2025-08-21T23:14:02Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2021-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1155/2022/7413231-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/247634-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/247634-
Descrição: dc.descriptionSonchus oleraceus L. is an edible and medicinal plant used to treat stomachache and gastric ailments around the world. Thus, this study aimed to determine the gastroprotective mode of action of hydroalcoholic extract of S. oleraceus (HES). Mice were treated with HES before induction of gastric ulceration by ethanol/HCl. The area and histological appearance of ulcers were quantified, and mucus was measured histochemically. The effects of HES on inflammatory and oxidative markers were assessed in the ulcerated tissue. In addition, we investigated the gastric acid antisecretory activity of HES in pylorus-ligated rats. Chemical analyses of HES and its antioxidant activity were also performed in vitro. The HES (30 or 300 mg/kg) reduced the ulceration by 71.5 and 76.2%, respectively, compared with vehicle (p<0.001), and the histological analysis confirmed the macroscopic results with elevation in mucin levels by 361.4 and 477.5%, respectively, compared with vehicle (p<0.001). Moreover, the gastroprotection was accompanied by increases in GSH levels and in SOD, CAT, and GST activities; in parallel to a reduction in MPO activity and TNF levels. Furthermore, HES reduced the total acidity, and pepsin activity of the gastric juice of rats by 61 and 63%, respectively, compared to the vehicle. Phytochemical analysis indicated that luteolin-7-O-β-D-glucoside is the main active compound annotated in HES. Was also found that HES scavenged the DPPH radical with an IC50 of 15.41 μg/mL. In conclusion, the gastroprotective effects of HES involve reductions in oxidative stress and inflammatory injury, in conjunction with an increase in mucus layer and inhibition of gastric secretion. This study advances in elucidating the modes of the antiulcer potential of S. oleraceus and contributes to the prospection of new gastroprotective molecules.-
Descrição: dc.descriptionPostgraduate Program in Health Sciences Community University of Chapeco Region, SC-
Descrição: dc.descriptionPharmacognosy Laboratory Community University of Chapecó Region, SC-
Descrição: dc.descriptionPostgraduate Program in Pharmaceutical Sciences University of Vale Do Itajaí, SC-
Descrição: dc.descriptionInstitute of Biosciences São Paulo State University, São Vicente, Campus Litoral Paulista, SP-
Descrição: dc.descriptionPostgraduate Program in Development and Society Alto Vale Do Rio Do Peixe University, Caçador, SC-
Descrição: dc.descriptionInstitute of Biosciences São Paulo State University, São Vicente, Campus Litoral Paulista, SP-
Idioma: dc.languageen-
Relação: dc.relationEvidence-based Complementary and Alternative Medicine-
???dc.source???: dc.sourceScopus-
Título: dc.titleSonchus oleraceus L. Promotes Gastroprotection in Rodents via Antioxidant, Anti-Inflammatory, and Antisecretory Activities-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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