Effect of two combinations of low-dose oral contraceptives on adolescent bone mass: A clinical trial with 2 years follow-up

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorAssis Municipality Educational Foundation (FEMA)-
Autor(es): dc.contributorUniversidade Estadual de Londrina (UEL)-
Autor(es): dc.creatorCaldeirão, Talita Domingues-
Autor(es): dc.creatorOrsolini, Lilian Rodrigues-
Autor(es): dc.creatorDa Silva, Carla Cristiane-
Autor(es): dc.creatorBisi Rizzo, Anapaula Da Conceição-
Autor(es): dc.creatorTeixeira, Altamir Santos-
Autor(es): dc.creatorNunes, Hélio Rubens De Carvalho-
Autor(es): dc.creatorGoldberg, Tamara Beres Lederer-
Data de aceite: dc.date.accessioned2025-08-21T16:53:32Z-
Data de disponibilização: dc.date.available2025-08-21T16:53:32Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2022-09-16-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1097/MD.0000000000030680-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/247628-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/247628-
Descrição: dc.descriptionIntroduction: Most contraceptive combinations can interfere with the processes of bone formation and resorption. Aim: The aim of this study was to evaluate the effect of 2 combinations of low-dose oral hormonal contraceptives (20 µg ethinyl estradiol [EE]/150 mg desogestrel [COC1] or 30 µg EE/3 mg drospirenone [COC2]) on bone mass acquisition in adolescents over 2 years by means of bone densitometry and measurement of biomarkers of bone remodeling. Methods: Parallel-group, non-randomized controlled clinical trial of 127 adolescents divided into a control group and 2 groups receiving either COC1 or COC2. The participants were submitted to anthropometric assessment and evaluation of secondary sexual characteristics (Tanner criteria) and bone age. Bone densitometry by dual-energy X-ray absorptiometry and measurement of bone biomarkers (bone alkaline phosphatase, osteocalcin, and C-terminal telopeptide) were performed at baseline and after 24 months. Results: No significant differences in the variables analyzed were observed between COC1 or COC2 users and the control group at baseline. After 24 months, non-users had incorporated more bone mass (content and density) than either group of contraceptive users. This negative impact was more pronounced in the COC2 group than in the COC1 group. A significant reduction in the percentage values of bone alkaline phosphatase and osteocalcin was observed in users of oral contraceptives. Conclusion: Bone mass acquisition was compromised in adolescent users of combined hormonal contraceptives. The negative impact was more pronounced in adolescents using contraceptives that contain 30 µg EE/3 mg drospirenone.-
Descrição: dc.descriptionPostgraduate Program in Tocogynecology Botucatu Medical School São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionMedical School Assis Municipality Educational Foundation (FEMA), SP-
Descrição: dc.descriptionState University of Londrina UEL, Parana-
Descrição: dc.descriptionDepartment of Tropical Diseases and Diagnostic Imaging Botucatu Medical School São Paulo University (UNESP), São Paulo-
Descrição: dc.descriptionBotucatu Medical School São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionPostgraduate Program in Tocogynecology Botucatu Medical School São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionDepartment of Tropical Diseases and Diagnostic Imaging Botucatu Medical School São Paulo University (UNESP), São Paulo-
Descrição: dc.descriptionBotucatu Medical School São Paulo State University (UNESP), São Paulo-
Formato: dc.formatE30680-
Idioma: dc.languageen-
Relação: dc.relationMedicine (United States)-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectadolescents-
Palavras-chave: dc.subjectbone density-
Palavras-chave: dc.subjectbone remodeling-
Palavras-chave: dc.subjectbone resorption-
Palavras-chave: dc.subjecthormonal contraceptives-
Palavras-chave: dc.subjectpeak height velocity (PHV)-
Título: dc.titleEffect of two combinations of low-dose oral contraceptives on adolescent bone mass: A clinical trial with 2 years follow-up-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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