Effect of sodium hexametaphosphate and quercetin, associated or not with fluoride, on dentin erosion in vitro

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Michigan-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorCapalbo, Letícia Cabrera-
Autor(es): dc.creatorDelbem, Alberto Carlos Botazzo-
Autor(es): dc.creatorDal-Fabbro, Renan-
Autor(es): dc.creatorInácio, Kelly Karina-
Autor(es): dc.creatorde Oliveira, Rodrigo Cardoso-
Autor(es): dc.creatorPessan, Juliano Pelim-
Data de aceite: dc.date.accessioned2025-08-21T16:19:52Z-
Data de disponibilização: dc.date.available2025-08-21T16:19:52Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2022-10-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.archoralbio.2022.105541-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/247620-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/247620-
Descrição: dc.descriptionObjective: to investigate the ability of solutions containing sodium hexametaphosphate, fluoride and quercetin, alone or in association, to prevent dentin erosion and to inhibit matrix metalloproteinases -2 and -9 activity using in vitro protocols. Design: Root dentin blocks (n = 96) were prepared and divided into 8 experimental groups (n = 12/group), according to the solutions to be tested: Placebo; 0.24% sodium fluoride (F); 1.0% sodium hexametaphosphate (HMP); 0.03% quercetin (QC); F+HMP; F+QC; HMP+QC; and F+HMP+QC. Erosive challenges were performed 4×/day for 5 days. Specimens were treated with the respective solutions for one minute, twice a day. Next, dentin loss (profilometry) and integrated hardness area in depth (KHN × µm) were determined. The antiproteolytic potential was assessed by gelatin zymography. Dentin erosion results (log10-transformed) were submitted to one-way ANOVA, followed by Tukey's test. Integrated hardness area in depth data (raw) were submitted to two-way, repeated-measures ANOVA, followed by Holm-Sidak's test (p<0.05). Results: Dentin erosion was significantly lower for F+HMP+QC than for all other treatments. At the shallowest depths (5–30 µm), blocks treated with F+HMP+QC had the highest integrated hardness area in depth values. All treatments completely inhibited matrix metalloproteinases-2 activity, except for the group QC (77% inhibition). For matrix metalloproteinases-9, all HMP-containing solutions or F+QC promoted total antiproteolytic activity. Conclusion: The association of fluoride, sodium hexametaphosphate, and quercetin must be considered a valuable strategy for novel product formulation for home and professional use, considering its superior protective effects against dentin erosion and its antiproteolytic potential.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionDepartment of Preventive and Restorative Dentistry School of Dentistry Araçatuba São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Cariology Restorative Sciences and Endodontics University of Michigan, MI-
Descrição: dc.descriptionDepartment of Biological Sciences Bauru School of Dentistry University of São Paulo, SP-
Descrição: dc.descriptionDepartment of Preventive and Restorative Dentistry School of Dentistry Araçatuba São Paulo State University (UNESP), SP-
Descrição: dc.descriptionFAPESP: #2019/02354-0-
Descrição: dc.descriptionCAPES: 001-
Idioma: dc.languageen-
Relação: dc.relationArchives of Oral Biology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectDentin-
Palavras-chave: dc.subjectMatrix metalloproteinase inhibitors-
Palavras-chave: dc.subjectPolyphosphates-
Palavras-chave: dc.subjectQuercetin-
Palavras-chave: dc.subjectTooth erosion-
Título: dc.titleEffect of sodium hexametaphosphate and quercetin, associated or not with fluoride, on dentin erosion in vitro-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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