Probiotic consumption can modify the resilience of periodontal tissues in rats under experimental periodontitis

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorGuarulhos University-
Autor(es): dc.creatorde Oliveira, Luiz Fernando Ferreira-
Autor(es): dc.creatorSilva, Pedro Henrique Felix-
Autor(es): dc.creatorSalvador, Sergio Luiz-
Autor(es): dc.creatorErvolino, Edilson-
Autor(es): dc.creatorCasarin, Renato-
Autor(es): dc.creatorFigueiredo, Luciene-
Autor(es): dc.creatorRicoldi, Milla Tavares-
Autor(es): dc.creatorde Souza, Sérgio Luís Scombatti-
Autor(es): dc.creatorFurlaneto, Flavia-
Autor(es): dc.creatorMessora, Michel Reis-
Data de aceite: dc.date.accessioned2025-08-21T19:40:31Z-
Data de disponibilização: dc.date.available2025-08-21T19:40:31Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-01-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1002/JPER.21-0555-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/247605-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/247605-
Descrição: dc.descriptionBackground: This study evaluated the effects of systemic administration of Bifidobacterium animalis subsp. lactis HN019 (B. lactis HN019) on experimental periodontitis (EP) in rats. Methods: Thirty-two rats were allocated to groups C (control), C-HN019 (probiotic), EP (EP only), and EP-HN019 (EP+probiotic). From day 0, the animals of C-HN019 and EP-HN019 groups received B. lactis HN019 (1 × 109 CFU/ml) daily. On the 14th day, the animals of EP and EP-HN019 groups received silk ligature around mandibular molars. Animals were euthanized on the 28th day. Samples of oral biofilm, gingival tissues, blood serum, and mandible were obtained for microtomographic, histomorphometric, microbiological, and immunological analyses. Data were statistically analyzed (p < 0.05). Results: Group EP-HN019 presented significantly less alveolar bone loss when compared with Group EP in histomorphometric and microtomographic analyses. In gingival tissue and serum, Group EP-HN019 presented lower proinflammatory/anti-inflammatory cytokines ratios than Group EP. Group EP-HN019 showed higher expression of beta-defensins and less TRAP-positive cells than Group EP. Group EP presented higher gene expression of Ifng and lower gene expression of Foxp3 when compared with Group EP-HN019 in gingival tissue. In oral biofilm, EP-HN019 group presented a lower percentage of species similar to Fusobacterium periodonticum and a higher percentage of species similar to Actinomyces gereneseriae, Actinomyces israelli, and Streptococcus gordonii when compared with Group EP. There was a significant increase of B. lactis HN019 after administration of probiotic therapy in oral biofilm of Group EP-HN019. Conclusion: The consumption of B. lactis HN019 promotes a protective effect against alveolar bone loss by modifying local and systemic microbiological and immunoinflammatory parameters.-
Descrição: dc.descriptionDepartment of Oral and Maxillofacial Surgery and Periodontology School of Dentistry of Ribeirão Preto University of São Paulo – USP, SP-
Descrição: dc.descriptionDepartment of Clinical Analyses School of Pharmaceutical Sciences of Ribeirão Preto University of São Paulo - USP, SP-
Descrição: dc.descriptionDepartment of Basic Sciences Division of Histology Dental School of Araçatuba São Paulo State University-
Descrição: dc.descriptionDepartment of Prosthodontics and Periodontics School of Dentistry Campinas State University-
Descrição: dc.descriptionDepartment of Periodontology Dental Research Division Guarulhos University-
Descrição: dc.descriptionDepartment of Basic Sciences Division of Histology Dental School of Araçatuba São Paulo State University-
Formato: dc.format217-229-
Idioma: dc.languageen-
Relação: dc.relationJournal of Periodontology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectbifidobacterium-
Palavras-chave: dc.subjecthost microbial interactions-
Palavras-chave: dc.subjectimmunology-
Palavras-chave: dc.subjectperiodontitis-
Palavras-chave: dc.subjectrats-
Título: dc.titleProbiotic consumption can modify the resilience of periodontal tissues in rats under experimental periodontitis-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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