ceRNA crosstalk mediated by ncRNAs is a novel regulatory mechanism in fish sex determination and differentiation

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorChinese Academy of Fishery Sciences-
Autor(es): dc.contributorPilot National Laboratory for Marine Science and Technology (Qingdao)-
Autor(es): dc.contributorIncorporated-
Autor(es): dc.contributorNanchang University-
Autor(es): dc.contributorOcean University of China-
Autor(es): dc.contributorRuhr University Bochum-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Do Algarve-
Autor(es): dc.contributorUniversity of Würzburg-
Autor(es): dc.contributorTexas State University-
Autor(es): dc.creatorTang, Lili-
Autor(es): dc.creatorHuang, Fei-
Autor(es): dc.creatorYou, Wuxin-
Autor(es): dc.creatorPoetsch, Ansgar-
Autor(es): dc.creatorNóbrega, Rafael Henrique-
Autor(es): dc.creatorPower, Deborah Mary-
Autor(es): dc.creatorZhu, Tengfei-
Autor(es): dc.creatorLiu, Kaiqiang-
Autor(es): dc.creatorWang, Hong-Yan-
Autor(es): dc.creatorWang, Qian-
Autor(es): dc.creatorXu, Xiwen-
Autor(es): dc.creatorFeng, Bo-
Autor(es): dc.creatorSchartl, Manfred-
Autor(es): dc.creatorShao, Changwei-
Data de aceite: dc.date.accessioned2025-08-21T20:17:15Z-
Data de disponibilização: dc.date.available2025-08-21T20:17:15Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2022-08-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1101/gr.275962.121-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/247602-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/247602-
Descrição: dc.descriptionCompeting endogenous RNAs (ceRNAs) are vital regulators of gene networks in mammals. The involvement of noncoding RNAs (ncRNAs) as ceRNA in genotypic sex determination (GSD) and environmental sex determination (ESD) in fish is unknown. The Chinese tongue sole, which has both GSD and ESD mechanisms, was used to map the dynamic expression pattern of ncRNAs and mRNA in gonads during sex determination and differentiation. Transcript expression patterns shift during the sex differentiation phase, and ceRNA modulation occurs through crosstalk of differentially expressed long ncRNAs (lncRNAs), circular RNAs (circRNAs), microRNAs (miRNAs), and sex-related genes in fish. Of note was the significant up-regulation of a circRNA from the sex-determining gene dmrt1 (circular RNA dmrt1) and a lncRNA, called AMSDT (which stands for associated with male sex differentiation of tongue sole) in Chinese tongue sole testis. These two ncRNAs both share the same miRNA response elements with gsdf, which has an up-regulated expression when they bind to miRNA cse-miR-196 and concurrent down-regulated female sex-related genes to facilitate testis differentiation. This is the first demonstration in fish that ceRNA crosstalk mediated by ncRNAs modulates sexual development and unveils a novel regulatory mechanism for sex determination and differentiation.-
Descrição: dc.descriptionTexas State University-
Descrição: dc.descriptionQingdao National Laboratory for Marine Science and Technology-
Descrição: dc.descriptionKey Lab of Sustainable Development of Marine Fisheries Ministry of Agriculture and Rural Affairs Yellow Sea Fisheries Research Institute Chinese Academy of Fishery Sciences, Shandong-
Descrição: dc.descriptionLaboratory for Marine Fisheries Science and Food Production Processes Pilot National Laboratory for Marine Science and Technology (Qingdao), Shandong-
Descrição: dc.descriptionGenosys Incorporated, Guangdong-
Descrição: dc.descriptionNCU-QMUL Joint Research Institute of Precision Medical Sciences Queen Mary School Nanchang University-
Descrição: dc.descriptionCollege of Marine Life Science Ocean University of China, Shandong-
Descrição: dc.descriptionLaboratory for Marine Biology and Biotechnology Pilot National Laboratory for Marine Science and Technology (Qingdao), Shandong-
Descrição: dc.descriptionDepartment of Plant Biochemistry Ruhr University Bochum, North Rhine-Westphalia-
Descrição: dc.descriptionInstitute of Biosciences Department of Structural and Functional Biology Division Morphology Reproductive and Molecular Biology Group São Paulo State University, Botucatu-
Descrição: dc.descriptionComparative Endocrinology and Integrative Biology Centre of Marine Sciences Universidade Do Algarve Campus De Gambelas, Algarve-
Descrição: dc.descriptionDevelopmental Biochemistry Biocenter University of Würzburg, Bayern-
Descrição: dc.descriptionThe Xiphophorus Genetic Stock Center Department of Chemistry and Biochemistry Texas State University-
Descrição: dc.descriptionInstitute of Biosciences Department of Structural and Functional Biology Division Morphology Reproductive and Molecular Biology Group São Paulo State University, Botucatu-
Descrição: dc.descriptionQingdao National Laboratory for Marine Science and Technology: 2017ASTCP-ES06-
Formato: dc.format1502-1515-
Idioma: dc.languageen-
Relação: dc.relationGenome Research-
???dc.source???: dc.sourceScopus-
Título: dc.titleceRNA crosstalk mediated by ncRNAs is a novel regulatory mechanism in fish sex determination and differentiation-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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