Evaluation of Euphorbia tirucalli L. immunomodulatory and Antitumor Activity

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Autor(es): dc.contributorFederal University of Mato Grosso-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorNery, Eduardo Figueredo-
Autor(es): dc.creatorKelly, Taiany Oliveira-
Autor(es): dc.creatorRodrigues, Paloma Filomena Gouveia-
Autor(es): dc.creatorAlbiero, Lucineia Reuse-
Autor(es): dc.creatorDalazen, Jeniffer Charlene-
Autor(es): dc.creatorPereira, Débora Linsbinski-
Autor(es): dc.creatorCastoldi, Lindsey-
Data de aceite: dc.date.accessioned2025-08-21T18:35:15Z-
Data de disponibilização: dc.date.available2025-08-21T18:35:15Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2022-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.21664/2238-8869.2023V12I1.P56-70-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/247533-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/247533-
Descrição: dc.descriptionEuphorbia tirucalli L. is commonly used to treat various pathologies, including cancer. The objective of this study was to evaluate the effect of a crude extract of E. tirucalli on the development of Ehrlich solid tumors and immune function. We prepared an extract by macerating the aerial parts of the plant with 80% ethanol (1:10 g/v) for 15 days. Its effects on tumor development were assessed in male Swiss mice (n=10). The mice were injected subcutaneously with 106 tumor cells and then treated by gavage daily with the extract (33.33, 67, and 133.34 mg kg-1) or saline (0.5% ethanol) for 30 days. The treatment had no toxic effect and did not reduce tumor growth. However, the weight of tumor mass was lowest in the mice treated with extract at 67 mg kg-1. Immunomodulatory activity was evaluated in mice (n=8), with and without tumors, treated with the extract (67 mg kg-1), under the same conditions as described above for 7 and 14 days. Lymphoproliferation, NK activity and IL-12, TNF-α, IFN- γ, and IL-10 levels did not differ significantly between the groups. However, IL-4 levels were reduced in the E. tirucalli treated groups at 7 and 14 days when compared to the controls. We concluded that the extract is not toxic and cannot inhibit Ehrlich solid tumor development. Its immunomodulatory activity involves its ability to modulate IL-4 levels.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado da Bahia-
Descrição: dc.descriptionFelix Scholarship-
Descrição: dc.descriptionEnfermeiro Health Sciences Institute Federal University of Mato Grosso, Mato Grosso-
Descrição: dc.descriptionImunologia Básica - USP Faculty of Technologies of Sinop, Mato Grosso-
Descrição: dc.descriptionCiências Ambientais - UFMT Sciences Institute Federal University of Mato Grosso, Mato Grosso-
Descrição: dc.descriptionPatologia - UNESP Health Sciences Institute Federal University of Mato Grosso, Mato Grosso-
Descrição: dc.descriptionPatologia - UNESP Health Sciences Institute Federal University of Mato Grosso, Mato Grosso-
Formato: dc.format56-70-
Idioma: dc.languageen-
Relação: dc.relationFronteiras-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectaveloz-
Palavras-chave: dc.subjectEhrlich tumor-
Palavras-chave: dc.subjectEuphorbia tirucalli L-
Palavras-chave: dc.subjectimmunomodulation-
Título: dc.titleEvaluation of Euphorbia tirucalli L. immunomodulatory and Antitumor Activity-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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