Antimicrobial Peptide Arsenal Predicted from the Venom Gland Transcriptome of the Tropical Trap-Jaw Ant Odontomachus chelifer

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Autor(es): dc.contributorUniversidade Federal de São Carlos (UFSCar)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorFederal University of Uber-lândia (UFU)-
Autor(es): dc.contributorFudan University-
Autor(es): dc.creatorMenk, Josilene J.-
Autor(es): dc.creatorMatuhara, Yan E.-
Autor(es): dc.creatorSebestyen-França, Henrique-
Autor(es): dc.creatorHenrique-Silva, Flávio-
Autor(es): dc.creatorFerro, Milene-
Autor(es): dc.creatorRodrigues, Renata S.-
Autor(es): dc.creatorSantos-Júnior, Célio D.-
Data de aceite: dc.date.accessioned2025-08-21T23:42:20Z-
Data de disponibilização: dc.date.available2025-08-21T23:42:20Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-05-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/toxins15050345-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/247453-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/247453-
Descrição: dc.descriptionWith about 13,000 known species, ants are the most abundant venomous insects. Their venom consists of polypeptides, enzymes, alkaloids, biogenic amines, formic acid, and hydrocarbons. In this study, we investigated, using in silico techniques, the peptides composing a putative antimicrobial arsenal from the venom gland of the neotropical trap-jaw ant Odontomachus chelifer. Focusing on transcripts from the body and venom gland of this insect, it was possible to determine the gland secretome, which contained about 1022 peptides with putative signal peptides. The majority of these peptides (75.5%) were unknown, not matching any reference database, motivating us to extract functional insights via machine learning-based techniques. With several complementary methodologies, we investigated the existence of antimicrobial peptides (AMPs) in the venom gland of O. chelifer, finding 112 non-redundant candidates. Candidate AMPs were predicted to be more globular and hemolytic than the remaining peptides in the secretome. There is evidence of transcription for 97% of AMP candidates across the same ant genus, with one of them also verified as translated, thus supporting our findings. Most of these potential antimicrobial sequences (94.8%) matched transcripts from the ant’s body, indicating their role not solely as venom toxins.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionLaboratory of Molecular Biology Department of Genetics and Evolution Federal University of São Carlos (UFSCar), Rodovia Washington Luis, Km 235, SP-
Descrição: dc.descriptionDepartment of General and Applied Biology Institute of Biosciences São Paulo State University (UNESP), SP-
Descrição: dc.descriptionLaboratory of Biochemistry and Animal Toxins Institute of Biotechnology Federal University of Uber-lândia (UFU), MG-
Descrição: dc.descriptionBig Data Biology Laboratory Institute of Science and Technology for Brain-Inspired Intelligence Fudan University-
Descrição: dc.descriptionDepartment of General and Applied Biology Institute of Biosciences São Paulo State University (UNESP), SP-
Descrição: dc.descriptionCNPq: CNPq 142046/2022-1-
Descrição: dc.descriptionCNPq: CNPq 315618/2021-3-
Idioma: dc.languageen-
Relação: dc.relationToxins-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectantimicrobial peptides-
Palavras-chave: dc.subjectneotropical ants-
Palavras-chave: dc.subjectprospection of peptides-
Palavras-chave: dc.subjectstinging ants-
Palavras-chave: dc.subjectvenom peptides-
Palavras-chave: dc.subjectvenomous ants-
Título: dc.titleAntimicrobial Peptide Arsenal Predicted from the Venom Gland Transcriptome of the Tropical Trap-Jaw Ant Odontomachus chelifer-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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