Proposing Clinicopathological Staging and Mitotic Count as Prognostic Factors for Canine Soft Tissue Sarcomas

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorEletro-Onkovet Service-
Autor(es): dc.contributorOnccarevet Clinic-
Autor(es): dc.contributorAnhembi University-
Autor(es): dc.contributorArena235 Research Lab-
Autor(es): dc.contributorPaulista University (UNIP)-
Autor(es): dc.contributorVeterinary Oncology Service (SEOVET)-
Autor(es): dc.creatorCardoso de Almeida Moreira, Andrea Regina-
Autor(es): dc.creatorFranzoni, Mayara Simão-
Autor(es): dc.creatordos Anjos, Denner Santos-
Autor(es): dc.creatorCésar-Jark, Paulo-
Autor(es): dc.creatorNóbrega, Juliano-
Autor(es): dc.creatorLaufer-Amorim, Renée-
Autor(es): dc.creatorValsecchi Henriques, Marina-
Autor(es): dc.creatorNeto, Osmar Pinto-
Autor(es): dc.creatorFonseca-Alves, Carlos Eduardo-
Data de aceite: dc.date.accessioned2025-08-21T18:57:58Z-
Data de disponibilização: dc.date.available2025-08-21T18:57:58Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-05-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/vetsci10050327-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/247451-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/247451-
Descrição: dc.descriptionSoft tissue sarcomas (STSs) are a heterogeneous group of malignant mesenchymal tumors with similar histological features and biological behaviors. They are characterized by a low to moderate local recurrence rate and low metastasis, affecting approximately 20% of patients. Although this tumor set is vital in veterinary medicine, no previous unified staging system or mitotic count has been associated with patient prognosis. Therefore, this study proposed a new clinicopathological staging method and evaluated a cut-off value for mitosis related to the survival of dogs affected by STS. This study included 105 dogs affected by STS, treated only with surgery, and a complete follow-up evaluation. The new clinicopathological staging system evaluated tumor size (T), nodal involvement (N), distant metastasis (M), and histological grading criteria (G) to categorize the tumor stage into four groups (stages I, II, III, and IV). The proposed tumor staging system was able to differentiate patients’ prognoses, with dogs with stage IV disease experiencing the lowest survival time and dogs with stage I disease having the highest survival time (p < 0.001). Moreover, we assessed the median mitosis (based on mitotic count) and its association with overall survival. Our study’s median mitosis was 5, and patients with ≤5 mitoses had a higher survival time (p = 0.006). Overall, the proposed staging system and mitotic count seemed promising in the prediction of patient prognosis.-
Descrição: dc.descriptionDepartment of Veterinary Clinic School of Veterinary Medicine and Science São Paulo State University (UNESP)-
Descrição: dc.descriptionEletro-Onkovet Service-
Descrição: dc.descriptionOnccarevet Clinic-
Descrição: dc.descriptionBiomedical Engineering Department Anhembi University-
Descrição: dc.descriptionArena235 Research Lab-
Descrição: dc.descriptionInstitute of Health Sciences Paulista University (UNIP)-
Descrição: dc.descriptionVeterinary Oncology Service (SEOVET)-
Descrição: dc.descriptionDepartment of Veterinary Clinic School of Veterinary Medicine and Science São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationVeterinary Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectcanine-
Palavras-chave: dc.subjectmesenchymal tissues-
Palavras-chave: dc.subjectoverall survival-
Palavras-chave: dc.subjectsarcomas-
Título: dc.titleProposing Clinicopathological Staging and Mitotic Count as Prognostic Factors for Canine Soft Tissue Sarcomas-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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