Association between Clinical and Histopathological Findings in Intestinal Neuronal Dysplasia Type B: An Advance towards Its Definition as a Disease

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorGonçalves, Anderson Cesar-
Autor(es): dc.creatorde Faria Oliveira, Isabelle Stefan-
Autor(es): dc.creatorHamamoto Filho, Pedro Tadao-
Autor(es): dc.creatorOrtolan, Erika Veruska Paiva-
Autor(es): dc.creatorTerra, Simone Antunes-
Autor(es): dc.creatorRodrigues, Maria Aparecida Marchesan-
Autor(es): dc.creatorde Arruda Lourenção, Pedro Luiz Toledo-
Data de aceite: dc.date.accessioned2025-08-21T22:54:56Z-
Data de disponibilização: dc.date.available2025-08-21T22:54:56Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-05-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/life13051175-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/247438-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/247438-
Descrição: dc.descriptionIntroduction: Intestinal neuronal dysplasia type B (IND-B) is a controversial entity that affects the submucosal nerve plexus of the distal intestine. The lack of definition of the causal relationship between histological findings and clinical symptoms has been identified as the primary point to be elucidated in the scientific investigation related to IND-B, which is essential for it to be considered a disease. Objective: To investigate the relationship between histopathological findings and symptoms in a series of patients with IND-B. Methods: Twenty-seven patients with histopathological diagnosis of IND-B, according to the Frankfurt Consensus (1990), who underwent surgical treatment through colorectal resections were included. Data from medical records regarding the clinical picture of the patients at the time of diagnosis, including the intestinal symptom index (ISI) and a detailed histopathological analysis of the rectal specimens, were retrieved. Exploratory factor analysis was performed, applying the principal components method for clusters with Varimax rotation. Results: Two factors were determined: the first, determined by histopathological and clinical variables, and the second, composed of the main symptoms presented in patients with IND-B, including ISI. Factorial rotation showed the association between the two factors and, through a graph, demonstrated the proximity between ISI values and histopathological alterations. Conclusion: There was evidence of an association between the clinical features presented by patients with IND-B and the histopathological findings of the rectal samples. These results support the understanding of IND-B as a disease.-
Descrição: dc.descriptionBotucatu Medical School São Paulo State University (UNESP)-
Descrição: dc.descriptionBotucatu Medical School São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationLife-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectchildren-
Palavras-chave: dc.subjectconstipation-
Palavras-chave: dc.subjectintestinal neuronal dysplasia type B-
Título: dc.titleAssociation between Clinical and Histopathological Findings in Intestinal Neuronal Dysplasia Type B: An Advance towards Its Definition as a Disease-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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