First report on the toxicity of SARS-CoV-2, alone and in combination with polyethylene microplastics in neotropical fish

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Autor(es): dc.contributorGoiano Federal Institute-
Autor(es): dc.contributorBegum Rokeya University-
Autor(es): dc.contributorJahangirnagar University-
Autor(es): dc.contributorSaveetha Institute of Medical and Technical Sciences (SIMATS)-
Autor(es): dc.contributorSRM Institute of Science and Technology (SRMIST)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorFederal University of Ceará-
Autor(es): dc.contributorCONICET Instituto Argentino de Oceanografía (IADO)-
Autor(es): dc.contributorUniversidad Autónoma de San Luis Potosí-
Autor(es): dc.contributorScientific and Technological Park of the University of Girona-
Autor(es): dc.contributorInstitute of Environmental Assessment and Water Research (IDAEA-CSIC)-
Autor(es): dc.contributorUniversidade Federal de Uberlândia (UFU)-
Autor(es): dc.contributorUniversidade Federal de Goiás (UFG)-
Autor(es): dc.contributorBrazilian Academy of Young Scientists (ABJC)-
Autor(es): dc.creatorFerreira, Raíssa de Oliveira-
Autor(es): dc.creatorGuimarães, Abraão Tiago Batista-
Autor(es): dc.creatorLuz, Thiarlen Marinho da-
Autor(es): dc.creatorRodrigues, Aline Sueli de Lima-
Autor(es): dc.creatorIslam, Abu Reza Md. Towfiqul-
Autor(es): dc.creatorRahman, Md. Mostafizur-
Autor(es): dc.creatorRagavendran, Chinnasamy-
Autor(es): dc.creatorKamaraj, Chinnaperumal-
Autor(es): dc.creatorCharlie-Silva, Ives-
Autor(es): dc.creatorDurigon, Edison Luiz-
Autor(es): dc.creatorBraz, Helyson Lucas Bezerra-
Autor(es): dc.creatorArias, Andrés Hugo-
Autor(es): dc.creatorSantiago, Omar Cruz-
Autor(es): dc.creatorBarceló, Damià-
Autor(es): dc.creatorMalafaia, Guilherme-
Data de aceite: dc.date.accessioned2025-08-21T21:06:48Z-
Data de disponibilização: dc.date.available2025-08-21T21:06:48Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-15-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.scitotenv.2023.163617-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/247236-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/247236-
Descrição: dc.descriptionThe COVID-19 pandemic has caused unprecedented negative impacts in the modern era, including economic, social, and public health losses. On the other hand, the potential effects that the input of SARS-CoV-2 in the aquatic environment from sewage may represent on non-target organisms are not well known. In addition, it is not yet known whether the association of SARS-CoV-2 with other pollutants, such as microplastics (MPs), may further impact the aquatic biota. Thus, we aimed to evaluate the possible ecotoxicological effects of exposure of male adults Poecilia reticulata, for 15 days, to inactivated SARS-CoV-2 (0.742 pg/L; isolated SARS.CoV2/SP02.2020.HIAE.Br) and polyethylene MP (PE MPs) (7.1 × 104 particles/L), alone and in combination, from multiple biomarkers. Our data suggest that exposure to SARS-CoV-2 induced behavioral changes (in the open field test), nephrotoxic effect (inferred by the increase in creatinine), hepatotoxic effect (inferred by the increase in bilirubin production), imbalance in the homeostasis of Fe, Ca, and Mg, as well as an anticholinesterase effect in the animals [marked by the reduction of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activity]. On the other hand, exposure to PE MPs induced a genotoxic effect (assessed by the comet assay), as well as an increase in enzyme activity alpha-amylase, alkaline phosphatase, and carboxylesterases. However, we did not show synergistic, antagonistic, or additive effects caused by the combined exposure of P. reticulata to SARS-CoV-2 and PE MPs. Principal component analysis (PCA) and values from the “Integrated Biomarker Response” index indicate that exposure to SARS-CoV-2 was determinant for a more prominent effect in the evaluated animals. Therefore, our study sheds light on the ecotoxicity of the new coronavirus in non-target organisms and ratifies the need for more attention to the impacts of COVID-19 on aquatic biota.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de Goiás-
Descrição: dc.descriptionFundação de Apoio à Pesquisa, Universidade Federal de Goiás-
Descrição: dc.descriptionLaboratory of Toxicology Applied to the Environment Goiano Federal Institute, GO-
Descrição: dc.descriptionPost-Graduation Program in Conservation of Cerrado Natural Resources Goiano Federal Institute, GO-
Descrição: dc.descriptionBegum Rokeya University Department of Disaster Management-
Descrição: dc.descriptionLaboratory of Environmental Health and Ecotoxicology Department of Environmental Sciences Jahangirnagar University-
Descrição: dc.descriptionDepartment of Conservative Dentistry and Endodontics Saveetha Dental College and Hospitals Saveetha Institute of Medical and Technical Sciences (SIMATS)-
Descrição: dc.descriptionInterdisciplinary Institute of Indian System of Medicine (IIISM) Directorate of Research and Virtual Education SRM Institute of Science and Technology (SRMIST), Tamil Nadu-
Descrição: dc.descriptionChemistry Institute São Paulo State University (UNESP) Campus Araraquara-
Descrição: dc.descriptionLaboratory of Clinical and Molecular Virology Institute of Biomedical Sciences University of São Paulo-
Descrição: dc.descriptionLaboratory of Toxicology Federal University of Ceará-
Descrição: dc.descriptionNational University of the South Bahía Blanca CONICET Instituto Argentino de Oceanografía (IADO)-
Descrição: dc.descriptionMultidisciplinary Postgraduate Program for Environmental Sciences Universidad Autónoma de San Luis Potosí-
Descrição: dc.descriptionCatalan Institute for Water Research (ICRA-CERCA) Scientific and Technological Park of the University of Girona, H2O Building, Emili Grahit 101-
Descrição: dc.descriptionWater and Soil Quality Research Group Department of Environmental Chemistry Institute of Environmental Assessment and Water Research (IDAEA-CSIC), JordiGirona 1826-
Descrição: dc.descriptionPost-Graduation Program in Ecology Conservation and Biodiversity Federal University of Uberlândia, MG-
Descrição: dc.descriptionPost-Graduation Program in Biotechnology and Biodiversity Federal University of Goiás, GO-
Descrição: dc.descriptionBrazilian Academy of Young Scientists (ABJC)-
Descrição: dc.descriptionChemistry Institute São Paulo State University (UNESP) Campus Araraquara-
Idioma: dc.languageen-
Relação: dc.relationScience of the Total Environment-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAquatic pollution-
Palavras-chave: dc.subjectEcotoxicology-
Palavras-chave: dc.subjectNew coronavirus-
Palavras-chave: dc.subjectNon-target organisms-
Palavras-chave: dc.subjectPlastic particles-
Título: dc.titleFirst report on the toxicity of SARS-CoV-2, alone and in combination with polyethylene microplastics in neotropical fish-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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