Red biocolorant from endophytic Talaromyces minnesotensis: production, properties, and potential applications

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Autor(es): dc.contributorUniversidade Federal de São Carlos (UFSCar)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorSousa, Marina D. B.-
Autor(es): dc.creatorPereira, Murilo L.-
Autor(es): dc.creatorCruz, Felipe P. N.-
Autor(es): dc.creatorRomano, Luis H.-
Autor(es): dc.creatorAlbuquerque, Yulli R.-
Autor(es): dc.creatorCorreia, Ricardo O.-
Autor(es): dc.creatorOliveira, Fernanda M.-
Autor(es): dc.creatorPrimo, Fernando L.-
Autor(es): dc.creatorBaptista-Neto, Álvaro-
Autor(es): dc.creatorSousa, Cristina P.-
Autor(es): dc.creatorAnibal, Fernanda F.-
Autor(es): dc.creatorMoraes, Luiz Alberto B.-
Autor(es): dc.creatorBadino, Alberto C.-
Data de aceite: dc.date.accessioned2025-08-21T20:50:21Z-
Data de disponibilização: dc.date.available2025-08-21T20:50:21Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-06-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s00253-023-12491-7-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/247215-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/247215-
Descrição: dc.descriptionAbstract: Fungal colorants are gradually entering the global color market, given their advantages of being less harmful to human health, as well as having greater stability and biotechnological potential, compared to other natural sources. The present work concerns the isolation and identification of an endophytic filamentous fungus, together with the chemical characterization and assessment of the fluorescence, toxicity, stability, and application potential of its synthesized red colorant. The endophytic fungus was isolated from Hymenaea courbaril, a tree from the Brazilian savannah, and was identified as Talaromyces minnesotensis by phenotypic and genotypic characterization. Submerged cultivation of the fungus resulted in the production of approximately 12 AU500 of a red biocolorant which according to LC-DAD-MS analysis is characterized by being a complex mixture of molecules of the azaphilone class. Regarding cytotoxicity assays, activity against human hepatoblastoma (HepG2) cells was only observed at concentrations above 5.0 g L−1, while antimicrobial effects against pathogenic bacteria and yeast occurred at concentrations above 50.0 g L−1. The biocolorant showed high stability at neutral pH values and low temperatures (10 to 20 °C) and high half-life values (t1/2), which indicates potential versatility for application in different matrices, as observed in tests using detergent, gelatin, enamel, paint, and fabrics. The results demonstrated that the biocolorant synthesized by Talaromyces minnesotensis has potential for future biotechnological applications. Key Points: • An endophytic fungus, which was isolated and identified, synthesize a red colorant. • The colorant showed fluorescence property, low toxicity, and application potential. • The red biocolorant was highly stable at pH 8.0 and temperatures below 20°C. Graphical Abstract: [Figure not available: see fulltext.]-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionGraduate Program of Chemical Engineering Department of Chemical Engineering Federal University of São Carlos, C.P. 676, São Paulo-
Descrição: dc.descriptionChemical Engineering Undergraduate Course Department of Chemical Engineering Federal University of São Carlos, São Paulo-
Descrição: dc.descriptionGraduate Program of Biotechnology Department of Morphology and Pathology Federal University of São Carlos, São Paulo-
Descrição: dc.descriptionDepartment of Engineering of Bioprocess and Biotechnology School of Pharmaceutical Sciences São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionLaboratory of Microbiology and Biomolecules – LaMiB Department of Morphology and Pathology Federal University of São Carlos, São Paulo-
Descrição: dc.descriptionLaboratory of Inflammation and Infectious Diseases – LIDI Department of Morphology and Pathology Federal University of São Carlos, São Paulo-
Descrição: dc.descriptionGraduate Program of Chemistry Laboratory of Mass Spectrometry Applied to Natural Products Chemistry Department School of Philosophy Sciences and Languages University of São Paulo-
Descrição: dc.descriptionDepartment of Engineering of Bioprocess and Biotechnology School of Pharmaceutical Sciences São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionCNPq: 309728/2021-5-
Descrição: dc.descriptionCAPES: Finance Code 001-
Formato: dc.format3699-3716-
Idioma: dc.languageen-
Relação: dc.relationApplied Microbiology and Biotechnology-
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Palavras-chave: dc.subjectColor stability-
Palavras-chave: dc.subjectEndophytic fungus-
Palavras-chave: dc.subjectFungal pigment-
Palavras-chave: dc.subjectRed biocolorant-
Palavras-chave: dc.subjectTalaromyces minnesotensis-
Título: dc.titleRed biocolorant from endophytic Talaromyces minnesotensis: production, properties, and potential applications-
Tipo de arquivo: dc.typelivro digital-
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