Statin exposure during pregnancy promotes neuromuscular junction alterations in postpartum Wistar rats

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorMuller, Kevin Silva-
Autor(es): dc.creatorTibúrcio, Felipe Cantore-
Autor(es): dc.creatorde Barros, Jorge Willian Franco-
Autor(es): dc.creatorMatsumura, Cintia Yuri-
Autor(es): dc.creatorMatheus, Selma Maria Michelin-
Data de aceite: dc.date.accessioned2025-08-21T22:17:35Z-
Data de disponibilização: dc.date.available2025-08-21T22:17:35Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-06-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1002/mus.27825-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/247178-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/247178-
Descrição: dc.descriptionIntroduction/Aims: The mechanisms that underlie the pathogenesis of statin-associated muscle symptoms (SAMS) remain unclear. Pregnancy is associated with increased cholesterol levels. Statins may be useful during pregnancy, but their safety is uncertain. Hence, we investigated the postpartum effects of exposure to rosuvastatin and simvastatin during pregnancy in Wistar rats, targeting the neuromuscular structures. Methods: Twenty-one pregnant Wistar rats were divided into three groups: control (C) treated with vehicle (dimethylsulfoxide + dH20), simvastatin (S) 62.5 mg/kg/day, and rosuvastatin (R) 10 mg/kg/day. Gavage was performed daily from the gestational days 8 to 20. At weaning, the postpartum mother tissues were collected and subjected to morphological and morphometric analysis of the soleus muscle, associated neuromuscular junctions (NMJs), and the sciatic nerve; protein quantification; quantification of the cholesterol and creatine kinase in the serum; and intramuscular collagen analysis. Results: An increase in morphometric parameters (area, maximum and minimum diameters, Feret diameter, and minimum Feret) was observed in NMJs from the S and R groups in comparison with the C group, and there was also a loss of common NMJ circularity. The number of myofibers with central nuclei was higher in S (17 ± 3.9, P =.0083) and R (18.86 ± 14.42, P =.0498) than in C (6.8 ± 2.6). Discussion: Gestational exposure to statins induced postpartum NMJ morphology alterations in soleus muscle, which may be caused by the remodeling of clusters of nicotinic acetylcholine receptors. This may be associated with the development and progression of SAMS observed in clinical practice.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDivision of Anatomy Department of Structural and Functional Biology São Paulo State University Institute of Biosciences-
Descrição: dc.descriptionGraduate Program in Surgery and Translational Medicine São Paulo State University Medical School-
Descrição: dc.descriptionDivision of Anatomy Department of Structural and Functional Biology São Paulo State University Institute of Biosciences-
Descrição: dc.descriptionGraduate Program in Surgery and Translational Medicine São Paulo State University Medical School-
Descrição: dc.descriptionFAPESP: 2021/03528-2-
Formato: dc.format537-547-
Idioma: dc.languageen-
Relação: dc.relationMuscle and Nerve-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectmyonuclei-
Palavras-chave: dc.subjectneuromuscular interaction-
Palavras-chave: dc.subjectnicotinic acetylcholine receptor-
Palavras-chave: dc.subjectpregnancy-
Palavras-chave: dc.subjectstatins-associated muscle symptoms-
Título: dc.titleStatin exposure during pregnancy promotes neuromuscular junction alterations in postpartum Wistar rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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