Diagnosis, Prognosis, and Treatment of Canine Hemangiosarcoma: A Review Based on a Consensus Organized by the Brazilian Association of Veterinary Oncology, ABROVET

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Paulista (UNIP)-
Autor(es): dc.contributorUniversidade Federal de Minas Gerais (UFMG)-
Autor(es): dc.contributorVETPAT—Animal Pathology & Molecular Biology-
Autor(es): dc.contributorOnccarevet e Onconnectionvet Clinic-
Autor(es): dc.contributorBotafogo Veterinary Hospital-
Autor(es): dc.contributorE+ Veterinary Specialties-
Autor(es): dc.contributorOnco Cane Veterinary-
Autor(es): dc.contributorClinical and Surgical Oncology-
Autor(es): dc.contributorUniversidade Metropolitana de Santos (UNIMES)-
Autor(es): dc.contributorVet Cancer Animal Oncology and Pathology-
Autor(es): dc.contributorEletro-Onkovet Service-
Autor(es): dc.contributorCRV Image—Veterinary Reference Center-
Autor(es): dc.contributorNeoPet Vet Oncology-
Autor(es): dc.contributorLessa Cardiology Vet-
Autor(es): dc.contributorMedVet Chicago-
Autor(es): dc.contributorMunicipal of Health of the State of São Paulo-
Autor(es): dc.creatorDe Nardi, Andrigo Barboza-
Autor(es): dc.creatorde Oliveira Massoco Salles Gomes, Cristina-
Autor(es): dc.creatorFonseca-Alves, Carlos Eduardo-
Autor(es): dc.creatorde Paiva, Felipe Noleto-
Autor(es): dc.creatorLinhares, Laís Calazans Menescal-
Autor(es): dc.creatorCarra, Gabriel João Unger-
Autor(es): dc.creatordos Santos Horta, Rodrigo-
Autor(es): dc.creatorRuiz Sueiro, Felipe Augusto-
Autor(es): dc.creatorJark, Paulo Cesar-
Autor(es): dc.creatorNishiya, Adriana Tomoko-
Autor(es): dc.creatorde Carvalho Vasconcellos, Carmen Helena-
Autor(es): dc.creatorUbukata, Rodrigo-
Autor(es): dc.creatorBatschinski, Karen-
Autor(es): dc.creatorSobral, Renata Afonso-
Autor(es): dc.creatorFernandes, Simone Crestoni-
Autor(es): dc.creatorBiondi, Luiz Roberto-
Autor(es): dc.creatorDe Francisco Strefezzi, Ricardo-
Autor(es): dc.creatorMatera, Julia Maria-
Autor(es): dc.creatorRangel, Marcelo Monte Mor-
Autor(es): dc.creatordos Anjos, Denner Santos-
Autor(es): dc.creatorBrunner, Carlos Henrique Maciel-
Autor(es): dc.creatorLaufer-Amorim, Renee-
Autor(es): dc.creatorCadrobbi, Karine Germano-
Autor(es): dc.creatorCirillo, Juliana Vieira-
Autor(es): dc.creatorMartins, Mauro Caldas-
Autor(es): dc.creatorde Paula Reis Filho, Nazilton-
Autor(es): dc.creatorSilva Lessa, Diego Fernando-
Autor(es): dc.creatorPortela, Roberta-
Autor(es): dc.creatorScarpa Carneiro, Carolina-
Autor(es): dc.creatorRicci Lucas, Sílvia Regina-
Autor(es): dc.creatorFukumasu, Heidge-
Autor(es): dc.creatorFeliciano, Marcus Antônio Rossi-
Autor(es): dc.creatorGomes Quitzan, Juliany-
Autor(es): dc.creatorDagli, Maria Lucia Zaidan-
Data de aceite: dc.date.accessioned2025-08-21T16:09:53Z-
Data de disponibilização: dc.date.available2025-08-21T16:09:53Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-04-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/cancers15072025-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/247156-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/247156-
Descrição: dc.descriptionHemangiosarcoma is a mesenchymal neoplasm originating in the endothelial cells of blood vessels; they can be classified as non-visceral and visceral types. Non-visceral hemangiosarcomas can affect the skin, subcutaneous tissues, and muscle tissues; visceral hemangiosarcomas can affect the spleen, liver, heart, lungs, kidneys, oral cavity, bones, bladder, uterus, tongue, and retroperitoneum. Among domestic species, dogs are most affected by cutaneous HSA. Cutaneous HSA represents approximately 14% of all HSA diagnosed in this species and less than 5% of dermal tumors, according to North American studies. However, Brazilian epidemiological data demonstrate a higher prevalence, which may represent 27 to 80% of all canine HSAs and 13.9% of all skin neoplasms diagnosed in this species. Cutaneous HSA most commonly affects middle-aged to elderly dogs (between 8 and 15 years old), with no gender predisposition for either the actinic or non-actinic forms. The higher prevalence of cutaneous HSA in some canine breeds is related to lower protection from solar radiation, as low skin pigmentation and hair coverage lead to greater sun exposure. Actinic changes, such as solar dermatosis, are frequent in these patients, confirming the influence of solar radiation on the development of this neoplasm. There are multiple clinical manifestations of hemangiosarcoma in canines. The diagnostic approach and staging classification of cutaneous HSAs are similar between the different subtypes. The definitive diagnosis is obtained through histopathological analysis of incisional or excisional biopsies. Cytology can be used as a presurgical screening test; however, it has little diagnostic utility in cases of HSA because there is a high risk of blood contamination and sample hemodilution. Surgery is generally the treatment of choice for dogs with localized non-visceral HSA without evidence of metastatic disease. Recently, electrochemotherapy (ECT) has emerged as an alternative therapy for the local ablative treatment of different neoplastic types; the use of radiotherapy for the treatment of dogs with cutaneous HSA is uncommon. There is greater consensus in the literature regarding the indications for adjuvant chemotherapy in subcutaneous and muscular HSA; doxorubicin is the most frequently used antineoplastic agent for subcutaneous and muscular subtypes and can be administered alone or in combination with other drugs. Other therapies include antiangiogenic therapy, photodynamic therapy, the association of chemotherapy with the metronomic dose, targeted therapies, and natural products. The benefits of these therapies are presented and discussed. In general, the prognosis of splenic and cardiac HSA is unfavorable. As a challenging neoplasm, studies of new protocols and treatment modalities are necessary to control this aggressive disease.-
Descrição: dc.descriptionDepartment of Veterinary Clinic and Surgery Universidade Estadual Paulista (UNESP)-
Descrição: dc.descriptionDepartment of Pathology School of Veterinary Medicine and Animal Science Universidade de São Paulo (USP)-
Descrição: dc.descriptionInstitute of Health Sciences Universidade Paulista (UNIP)-
Descrição: dc.descriptionDepartment of Veterinary Surgery and Animal Reproduction Universidade Estadual Paulista (UNESP)-
Descrição: dc.descriptionDepartment of Veterinary Medicine and Surgery Veterinary School Universidade Federal de Minas Gerais-
Descrição: dc.descriptionHistopathological Diagnosis Department VETPAT—Animal Pathology & Molecular Biology-
Descrição: dc.descriptionOnccarevet e Onconnectionvet Clinic-
Descrição: dc.descriptionSurgical and Clinical Oncology Botafogo Veterinary Hospital-
Descrição: dc.descriptionClinical and Surgical Oncology E+ Veterinary Specialties-
Descrição: dc.descriptionClinical Surgical and Palliative Care Oncology Onco Cane Veterinary-
Descrição: dc.descriptionSEOVET—Specialized Service in Veterinary Oncology Clinical and Surgical Oncology-
Descrição: dc.descriptionSmall Animal Internal Medicine Department School of Veterinary Medicine Universidade Metropolitana de Santos (UNIMES)-
Descrição: dc.descriptionDepartment of Veterinary Medicine Faculty of Animal Science and Food Engineering Universidade de São Paulo (USP)-
Descrição: dc.descriptionDepartment of Surgery School of Veterinary Medicine and Animal Science Universidade de São Paulo (USP)-
Descrição: dc.descriptionClinical and Surgical Oncology Vet Cancer Animal Oncology and Pathology-
Descrição: dc.descriptionEletro-Onkovet Service-
Descrição: dc.descriptionDepartment of Veterinary Clinic School of Veterinary Science and Animal Health Universidade Estadual Paulista (UNESP)-
Descrição: dc.descriptionCRV Image—Veterinary Reference Center-
Descrição: dc.descriptionNeoPet Vet Oncology-
Descrição: dc.descriptionLessa Cardiology Vet-
Descrição: dc.descriptionMedVet Chicago-
Descrição: dc.descriptionCity Hall of São Paulo Municipal of Health of the State of São Paulo-
Descrição: dc.descriptionDepartment of Internal Medicine School of Veterinary Medicine and Animal Science Universidade de São Paulo (USP)-
Descrição: dc.descriptionDepartment of Veterinary Clinic and Surgery Universidade Estadual Paulista (UNESP)-
Descrição: dc.descriptionDepartment of Veterinary Surgery and Animal Reproduction Universidade Estadual Paulista (UNESP)-
Descrição: dc.descriptionDepartment of Veterinary Clinic School of Veterinary Science and Animal Health Universidade Estadual Paulista (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationCancers-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectactinic-
Palavras-chave: dc.subjectangiosarcoma-
Palavras-chave: dc.subjectcutaneous-
Palavras-chave: dc.subjectdog-
Palavras-chave: dc.subjectendothelial tumors-
Palavras-chave: dc.subjectguidelines-
Palavras-chave: dc.subjectvisceral-
Título: dc.titleDiagnosis, Prognosis, and Treatment of Canine Hemangiosarcoma: A Review Based on a Consensus Organized by the Brazilian Association of Veterinary Oncology, ABROVET-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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