Exposure of adult zebrafish (Danio rerio) to SARS-CoV-2 at predicted environmentally relevant concentrations: Outspreading warns about ecotoxicological risks to freshwater fish

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Autor(es): dc.contributorGoiano Federal Institute-
Autor(es): dc.contributorUniversidade Federal de Goiás (UFG)-
Autor(es): dc.contributorUniversidade Federal de Uberlândia (UFU)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorBegum Rokeya University-
Autor(es): dc.contributorJahangirnagar University-
Autor(es): dc.contributorBrazilian Academy of Young Scientists (ABJC)-
Autor(es): dc.creatorLuz, Thiarlen Marinho da-
Autor(es): dc.creatorGuimarães, Abraão Tiago Batista-
Autor(es): dc.creatorMatos, Stênio Gonçalves da Silva-
Autor(es): dc.creatorde Souza, Sindoval Silva-
Autor(es): dc.creatorGomes, Alex Rodrigues-
Autor(es): dc.creatorRodrigues, Aline Sueli de Lima-
Autor(es): dc.creatorDurigon, Edison Luiz-
Autor(es): dc.creatorCharlie-Silva, Ives-
Autor(es): dc.creatorFreitas, Ítalo Nascimento-
Autor(es): dc.creatorIslam, Abu Reza Md. Towfiqul-
Autor(es): dc.creatorRahman, Md. Mostafizur-
Autor(es): dc.creatorSilva, Abner Marcelino-
Autor(es): dc.creatorMalafaia, Guilherme-
Data de aceite: dc.date.accessioned2025-08-21T22:35:52Z-
Data de disponibilização: dc.date.available2025-08-21T22:35:52Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.scitotenv.2023.163269-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/247143-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/247143-
Descrição: dc.descriptionWhile the multifaceted social, economic, and public health impacts associated with the COVID-19 pandemic are known, little is known about its effects on non-target aquatic ecosystems and organisms. Thus, we aimed to evaluate the potential ecotoxicity of SARS-CoV-2 lysate protein (SARS.CoV2/SP02.2020.HIAE.Br) in adult zebrafish (Danio rerio) at predicted environmentally relevant concentrations (0.742 and 2.226 pg/L), by 30 days. Although our data did not show locomotor alterations or anxiety-like or/and anxiolytic-like behavior, we noticed that exposure to SARS-CoV-2 negatively affected habituation memory and social aggregation of animals in response to a potential aquatic predator (Geophagus brasiliensis). An increased frequency of erythrocyte nuclear abnormalities was also observed in animals exposed to SARS-CoV-2. Furthermore, our data suggest that such changes were associated with a redox imbalance [↑ROS (reactive oxygen species), ↑H2O2 (hydrogen peroxide), ↓SOD (superoxide dismutase), and ↓CAT (catalase)], cholinesterasic effect [↑AChE (acetylcholinesterase) activity], as well as the induction of an inflammatory immune response [↑NO (nitric oxide), ↑IFN-γ (interferon-gamma), and ↓IL-10 (interleukin-10)]. For some biomarkers, we noticed that the response of the animals to the treatments was not concentration-dependent. However, principal component analysis (PCA) and the “Integrated Biomarker Response” index (IBRv2) indicated a more prominent ecotoxicity of SARS-CoV-2 at 2.226 pg/L. Therefore, our study advances knowledge about the ecotoxicological potential of SARS-CoV-2 and reinforces the presumption that the COVID-19 pandemic has negative implications beyond its economic, social, and public health impacts.-
Descrição: dc.descriptionInstituto Federal Goiás-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionLaboratory of Toxicology Applied to the Environment Goiano Federal Institute, GO-
Descrição: dc.descriptionPost-Graduation Program in Conservation of Cerrado Natural Resources Goiano Federal Institute, GO-
Descrição: dc.descriptionPost-Graduation Program in Biotechnology and Biodiversity Federal University of Goiás, GO-
Descrição: dc.descriptionPost-Graduation Program in Ecology Conservation and Biodiversity Federal University of Uberlândia, MG-
Descrição: dc.descriptionLaboratory of Clinical and Molecular Virology Institute of Biomedical Sciences University of São Paulo-
Descrição: dc.descriptionChemistry Institute São Paulo State University (UNESP) – Campus Araraquara-
Descrição: dc.descriptionBegum Rokeya University Department of Disaster Management-
Descrição: dc.descriptionLaboratory of Environmental Health and Ecotoxicology Department of Environmental Sciences Jahangirnagar University-
Descrição: dc.descriptionBrazilian Academy of Young Scientists (ABJC)-
Descrição: dc.descriptionChemistry Institute São Paulo State University (UNESP) – Campus Araraquara-
Descrição: dc.descriptionCNPq: 403065/2021-6-
Idioma: dc.languageen-
Relação: dc.relationScience of the Total Environment-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBiomarkers-
Palavras-chave: dc.subjectDanio rerio-
Palavras-chave: dc.subjectEcotoxicity-
Palavras-chave: dc.subjectEnvironmental toxicology-
Palavras-chave: dc.subjectNew coronavirus-
Título: dc.titleExposure of adult zebrafish (Danio rerio) to SARS-CoV-2 at predicted environmentally relevant concentrations: Outspreading warns about ecotoxicological risks to freshwater fish-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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