Could fluoride be considered a genotoxic chemical agent in vivo? A systematic review with meta-analysis

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Federal da Bahia (UFBA)-
Autor(es): dc.creatorDrummond, Giovana Wagner Branda-
Autor(es): dc.creatorTakeshita, Wilton Mitsunari-
Autor(es): dc.creatorde Castro, Glaucia Monteiro-
Autor(es): dc.creatordos Santos, Jean Nunes-
Autor(es): dc.creatorCury, Patricia Ramos-
Autor(es): dc.creatorRenno, Ana Claudia Muniz-
Autor(es): dc.creatorRibeiro, Daniel Araki-
Data de aceite: dc.date.accessioned2025-08-21T22:09:10Z-
Data de disponibilização: dc.date.available2025-08-21T22:09:10Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2022-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1080/09603123.2023.2194616-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/247136-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/247136-
Descrição: dc.descriptionThe goal of this study was to perform systematic review (SR) to investigate the scientific literature regarding the genotoxicity effects of fluoride exposure (FE). The search of databases used for this study was PubMed/Medline, SCOPUS and Web of Science. The quality of included studies was assessed using the EPHPP (Effective Public Health Practice Project). A total of 20 potentially relevant studies were selected for evaluating the genotoxicity induced by fluoride. Few studies have revealed that FE induces genotoxicity. A total of 14 studies demonstrated negative results whereas 6 studies did not. After reviewing the twenty studies, 1 was classified as weak, 10 were considered moderate and 9 were considered strong, according to the EPHPP. Taken together, it has been established that genotoxicity of fluoride is limited.-
Descrição: dc.descriptionDepartment of Biosciences Institute of Health and Society Federal University of São Paulo UNIFESP, SP-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery School of Dentistry São Paulo State University UNESP, SP-
Descrição: dc.descriptionSchool of Dentistry Federal University of Bahia UFBA-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery School of Dentistry São Paulo State University UNESP, SP-
Idioma: dc.languageen-
Relação: dc.relationInternational Journal of Environmental Health Research-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectcomet assay-
Palavras-chave: dc.subjectDNA damage-
Palavras-chave: dc.subjectfluoride-
Palavras-chave: dc.subjectGenotoxicity-
Palavras-chave: dc.subjectmicronucleus-
Título: dc.titleCould fluoride be considered a genotoxic chemical agent in vivo? A systematic review with meta-analysis-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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