Is micronucleus assay a suitable method for biomonitoring children exposed to X-ray? A systematic review with meta-analysis

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorMalacarne, Ingra Tais-
Autor(es): dc.creatorTakeshita, Wilton Mitsunari-
Autor(es): dc.creatorViana, Milena de Barros-
Autor(es): dc.creatorRenno, Ana Claudia Muniz-
Autor(es): dc.creatorRibeiro, Daniel Araki-
Data de aceite: dc.date.accessioned2025-08-21T22:10:14Z-
Data de disponibilização: dc.date.available2025-08-21T22:10:14Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2022-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1080/09553002.2023.2194405-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/247135-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/247135-
Descrição: dc.descriptionPurpose: The aim of this study was to evaluate if the micronucleus test using oral epithelial cells is a suitable biomarker for biomonitoring children exposed to X-ray. Material and methods: A search was performed through the electronic databases PubMed/Medline, Scopus, and Web of Science, all studies published up to February 2022 that examined the relationship between exposure of children to radiographic examinations and micronucleus. Results: A total of 17 full-text manuscripts were screened for eligibility. Only two studies found a difference in micronucleus labeling. On the other hand, all studies showed that X-ray was able to induce cellular death in oral mucosa cells. Following the parameters of the Effective Practices in Public Health Project (EPHPP), five manuscripts reached moderate and strong scores, and four studies were categorized as weak at final rating. In the meta-analysis, statistically significant difference was detected in micronucleated cells in children before and after radiographic examinations (SMD = 0.96, 95% CI, 0.07–1.84, p =.04), with τ2=1.09; χ2=53.37, and p <.001. Conclusion: Radiographic examinations in children can cause genotoxic and cytotoxic damage in the oral epithelium with a large effect size.-
Descrição: dc.descriptionDepartment of Biosciences Institute of Health and Society Federal University of São Paulo UNIFESP-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery School of Dentistry Sao Paulo State University UNESP-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery School of Dentistry Sao Paulo State University UNESP-
Idioma: dc.languageen-
Relação: dc.relationInternational Journal of Radiation Biology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectchildren-
Palavras-chave: dc.subjectMicronucleus assay-
Palavras-chave: dc.subjectoral mucosa-
Palavras-chave: dc.subjectX-ray-
Título: dc.titleIs micronucleus assay a suitable method for biomonitoring children exposed to X-ray? A systematic review with meta-analysis-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.