Macrophages CD163+ and Factor XIIIa+ Provide a First-Line Defence against Proliferative Verrucous Leukoplakia Antigens

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorThe University of Western Australia-
Autor(es): dc.creatorPalaçon, Mariana Paravani-
Autor(es): dc.creatorde Oliveira Barbeiro, Camila-
Autor(es): dc.creatorFernandes, Darcy-
Autor(es): dc.creatorBiancardi, Mariel Ruivo-
Autor(es): dc.creatorSilveira, Heitor Albergoni-
Autor(es): dc.creatorFerrisse, Túlio Morandin-
Autor(es): dc.creatorLeón, Jorge Esquiche-
Autor(es): dc.creatorKujan, Omar-
Autor(es): dc.creatorBufalino, Andreia-
Data de aceite: dc.date.accessioned2025-08-21T17:42:28Z-
Data de disponibilização: dc.date.available2025-08-21T17:42:28Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/ijms24065242-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/247133-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/247133-
Descrição: dc.descriptionThis study aimed to evaluate the density of the dendritic cells (DCs) and macrophages in oral leukoplakia (OL) and proliferative verrucous leukoplakia (PVL) by immunohistochemical analysis. We analysed paraffined tissue samples of PVL (n = 27), OL (n = 20), and inflammatory fibrous hyperplasia (n = 20) as the control group using the immunomarkers for DCs (CD1a, CD207, CD83, CD208 and CD123) and macrophages (CD68, CD163, FXIIIa and CD209). A quantitative analysis of positive cells in the epithelial and subepithelial areas was determined. Our results showed a reduction in CD208+ cells in the subepithelial area of the OL and PVL compared to the control. Additionally, we found a higher density of FXIIIa+ and CD163+ cells in the subepithelial area in PVL compared to the OL and control. Four-way MANOVA revealed a relationship between increased CD123+ cell density in the subepithelial area of “high-risk” samples regardless of disease. Macrophages provide the first line of defence against PVL antigens, suggesting a distinct pattern of innate immune system activation in PVL compared to OL, which may contribute to the complexity and the high rate of malignant transformation in the PVL.-
Descrição: dc.descriptionOral Medicine Department of Diagnosis and Surgery School of Dentistry São Paulo State University (Unesp), SP-
Descrição: dc.descriptionOral Pathology Department of Stomatology Public Oral and Forensic Dentistry Ribeirão Preto Dental School University of São Paulo (FORP/USP), SP-
Descrição: dc.descriptionUWA Dental School The University of Western Australia-
Descrição: dc.descriptionOral Medicine Department of Diagnosis and Surgery School of Dentistry São Paulo State University (Unesp), SP-
Idioma: dc.languageen-
Relação: dc.relationInternational Journal of Molecular Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectdendritic cells-
Palavras-chave: dc.subjectmacrophages-
Palavras-chave: dc.subjectmalignant transformation-
Palavras-chave: dc.subjectoral-
Palavras-chave: dc.subjectproliferative verrucous leukoplakia-
Título: dc.titleMacrophages CD163+ and Factor XIIIa+ Provide a First-Line Defence against Proliferative Verrucous Leukoplakia Antigens-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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