How Does Brazilian Green Propolis Act in Normal and Tumor Cells? Identification of Compounds in or out Monocytes or HEp-2 Cells

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorFarlow, Anthony-
Autor(es): dc.creatorJosé Crevelin, Eduardo-
Autor(es): dc.creatorBasso Santiago, Karina-
Autor(es): dc.creatorde Oliveira Cardoso, Eliza-
Autor(es): dc.creatorMatsumoto da Silva, Livia-
Autor(es): dc.creatorKenupp Bastos, Jairo-
Autor(es): dc.creatorMaurício Sforcin, José-
Data de aceite: dc.date.accessioned2025-08-21T23:08:00Z-
Data de disponibilização: dc.date.available2025-08-21T23:08:00Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-05-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1002/cbdv.202300348-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/247116-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/247116-
Descrição: dc.descriptionThe aim of this study was to identify propolis compounds after incubation of normal and tumor cells (monocytes and HEp-2 cells, respectively) with Brazilian green propolis, in the lysate and supernatant of cell cultures and within these cells by gas chromatography-mass spectrometry (GC/MS). Cinnamic acid derivatives were generally localized in the lysate of both cell lines after incubation, suggesting these compounds are actively transported across the membrane into the cytoplasm. Terpenes were also found in the lysate. Artepillin C, in contrast, was localised only in the supernatant. Some constituents were unobservable after incubation, especially in monocytes, suggesting the compounds had been degraded. Our findings shed light on the possible sites of action (intracellular or via a cell membrane protein) and the bioavailability of various constituents of propolis, as well as possible modes of delivery of bioactive constituents.-
Descrição: dc.descriptionDepartment of Chemical and Biological Sciences Institute of Biosciences São Paulo State University (UNESP), Campus Botucatu, SP-
Descrição: dc.descriptionDepartment of Chemistry School of Philosophy Sciences and Languages University of São Paulo (USP), SP-
Descrição: dc.descriptionDepartment of Pharmaceutical Sciences School of Pharmaceutical Sciences University of São Paulo (USP), SP-
Descrição: dc.descriptionDepartment of Chemical and Biological Sciences Institute of Biosciences São Paulo State University (UNESP), Campus Botucatu, SP-
Idioma: dc.languageen-
Relação: dc.relationChemistry and Biodiversity-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectchemical constituents-
Palavras-chave: dc.subjectGC/MS-
Palavras-chave: dc.subjectHEp-2 cells-
Palavras-chave: dc.subjectmonocytes-
Palavras-chave: dc.subjectpropolis-
Título: dc.titleHow Does Brazilian Green Propolis Act in Normal and Tumor Cells? Identification of Compounds in or out Monocytes or HEp-2 Cells-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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