Aging-Related Ovarian Failure and Infertility: Melatonin to the Rescue

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUT Health San Antonio-
Autor(es): dc.contributorComplutense University of Madrid-
Autor(es): dc.contributorConsejo Nacional de Investigaciones Cientificas y Tecnologicas (CONICET)-
Autor(es): dc.contributorFaculdade de Medicina de Sao Jose do Rio Preto-
Autor(es): dc.contributorInstitute of Biosciences of Botucatu-
Autor(es): dc.creatorReiter, Russel J.-
Autor(es): dc.creatorSharma, Ramaswamy-
Autor(es): dc.creatorRomero, Alejandro-
Autor(es): dc.creatorManucha, Walter-
Autor(es): dc.creatorTan, Dun-Xian-
Autor(es): dc.creatorZuccari, Debora Aparecida Pires de Campos-
Autor(es): dc.creatorChuffa, Luiz Gustavo de Almeida-
Data de aceite: dc.date.accessioned2025-08-21T22:04:01Z-
Data de disponibilização: dc.date.available2025-08-21T22:04:01Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/antiox12030695-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/247088-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/247088-
Descrição: dc.descriptionAging has a major detrimental effect on the optimal function of the ovary with changes in this organ preceding the age-related deterioration in other tissues, with the middle-aged shutdown leading to infertility. Reduced fertility and consequent inability to conceive by women in present-day societies who choose to have children later in life leads to increased frustration. Melatonin is known to have anti-aging properties related to its antioxidant and anti-inflammatory actions. Its higher follicular fluid levels relative to blood concentrations and its likely synthesis in the oocyte, granulosa, and luteal cells suggest that it is optimally positioned to interfere with age-associated deterioration of the ovary. Additionally, the end of the female reproductive span coincides with a significant reduction in endogenous melatonin levels. Thus, the aims are to review the literature indicating melatonin production in mitochondria of oocytes, granulosa cells, and luteal cells, identify the multiple processes underlying changes in the ovary, especially late in the cessation of the reproductive life span, summarize the physiological and molecular actions of melatonin in the maintenance of normal ovaries and in the aging ovaries, and integrate the acquired information into an explanation for considering melatonin in the treatment of age-related infertility. Use of supplemental melatonin may help preserve fertility later in life and alleviate frustration in women delaying childbearing age, reduce the necessity of in vitro fertilization–embryo transfer (IVF-ET) procedures, and help solve the progressively increasing problem of non-aging-related infertility in women throughout their reproductive life span. While additional research is needed to fully understand the effects of melatonin supplementation on potentially enhancing fertility, studies published to date suggest it may be a promising option for those struggling with infertility.-
Descrição: dc.descriptionDepartment of Cell Systems and Anatomy Joe R and Teresa Lozano Long School of Medicine UT Health San Antonio-
Descrição: dc.descriptionDepartment of Pharmacology and Toxicology Faculty of Veterinary Medicine Complutense University of Madrid-
Descrição: dc.descriptionInstituto de Medicina y Biologia Experimental de Cuyo (IMBECU) Consejo Nacional de Investigaciones Cientificas y Tecnologicas (CONICET)-
Descrição: dc.descriptionLaboratorio de Investigacao Molecular do Cancer Faculdade de Medicina de Sao Jose do Rio Preto-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences of Botucatu-
Idioma: dc.languageen-
Relação: dc.relationAntioxidants-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectextrapineal melatonin-
Palavras-chave: dc.subjectgranulosa cells-
Palavras-chave: dc.subjectin vitro fertilization–embryo transfer-
Palavras-chave: dc.subjectinflammation-
Palavras-chave: dc.subjectmitochondrial physiology-
Palavras-chave: dc.subjectoocyte-
Palavras-chave: dc.subjectoxidative stress-
Palavras-chave: dc.subjectreproductive life span-
Palavras-chave: dc.subjectsirtuins-
Título: dc.titleAging-Related Ovarian Failure and Infertility: Melatonin to the Rescue-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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