Brain washing and neural health: role of age, sleep, and the cerebrospinal fluid melatonin rhythm

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUT Health San Antonio-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorS.T. Bio-Life-
Autor(es): dc.contributorInstituto Mexicano del Seguro Social-
Autor(es): dc.contributorItalian Ministry of Defense-
Autor(es): dc.creatorReiter, Russel J.-
Autor(es): dc.creatorSharma, Ramaswamy-
Autor(es): dc.creatorCucielo, Maira Smaniotto-
Autor(es): dc.creatorTan, Dun Xian-
Autor(es): dc.creatorRosales-Corral, Sergio-
Autor(es): dc.creatorGancitano, Giuseppe-
Autor(es): dc.creatorde Almeida Chuffa, Luiz Gustavo-
Data de aceite: dc.date.accessioned2025-08-21T20:41:08Z-
Data de disponibilização: dc.date.available2025-08-21T20:41:08Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-04-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s00018-023-04736-5-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/247017-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/247017-
Descrição: dc.descriptionThe brain lacks a classic lymphatic drainage system. How it is cleansed of damaged proteins, cellular debris, and molecular by-products has remained a mystery for decades. Recent discoveries have identified a hybrid system that includes cerebrospinal fluid (CSF)-filled perivascular spaces and classic lymph vessels in the dural covering of the brain and spinal cord that functionally cooperate to remove toxic and non-functional trash from the brain. These two components functioning together are referred to as the glymphatic system. We propose that the high levels of melatonin secreted by the pineal gland directly into the CSF play a role in flushing pathological molecules such as amyloid-β peptide (Aβ) from the brain via this network. Melatonin is a sleep-promoting agent, with waste clearance from the CNS being highest especially during slow wave sleep. Melatonin is also a potent and versatile antioxidant that prevents neural accumulation of oxidatively-damaged molecules which contribute to neurological decline. Due to its feedback actions on the suprachiasmatic nucleus, CSF melatonin rhythm functions to maintain optimal circadian rhythmicity, which is also critical for preserving neurocognitive health. Melatonin levels drop dramatically in the frail aged, potentially contributing to neurological failure and dementia. Melatonin supplementation in animal models of Alzheimer’s disease (AD) defers Aβ accumulation, enhances its clearance from the CNS, and prolongs animal survival. In AD patients, preliminary data show that melatonin use reduces neurobehavioral signs such as sundowning. Finally, melatonin controls the mitotic activity of neural stem cells in the subventricular zone, suggesting its involvement in neuronal renewal.-
Descrição: dc.descriptionDepartment of Cell Systems and Anatomy Long School of Medicine UT Health San Antonio-
Descrição: dc.descriptionDepartment of Structural and Functional Biology-IBB/UNESP Institute of Biosciences of Botucatu Universidade Estadual Paulista, São Paulo-
Descrição: dc.descriptionS.T. Bio-Life-
Descrição: dc.descriptionCentro de Investigacion Biomedica de Occidente Instituto Mexicano del Seguro Social-
Descrição: dc.description1st “Tuscania” Paratrooper Regiment Italian Ministry of Defense-
Descrição: dc.descriptionDepartment of Structural and Functional Biology-IBB/UNESP Institute of Biosciences of Botucatu Universidade Estadual Paulista, São Paulo-
Idioma: dc.languageen-
Relação: dc.relationCellular and Molecular Life Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectApoptosis-
Palavras-chave: dc.subjectBrain metabolism-
Palavras-chave: dc.subjectBrain ventricles-
Palavras-chave: dc.subjectCSF flow-
Palavras-chave: dc.subjectDural lymphatics-
Palavras-chave: dc.subjectGlioblastoma-
Palavras-chave: dc.subjectGlymphatic system-
Palavras-chave: dc.subjectLumbar cistern-
Palavras-chave: dc.subjectNeurodegenerative diseases-
Palavras-chave: dc.subjectRedox homeostasis-
Palavras-chave: dc.subjectSubventricular zone-
Palavras-chave: dc.subjectTau protein-
Palavras-chave: dc.subjectVirchow-Robin perivascular spaces-
Título: dc.titleBrain washing and neural health: role of age, sleep, and the cerebrospinal fluid melatonin rhythm-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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