Effects of BlueM® against Streptococcus mutans biofilm and its virulence gene expression

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorSantos, Veronica Canela Estevam Dos-
Autor(es): dc.creatorMaquera-Huacho, Patricia Milagros-
Autor(es): dc.creatorImbriani, Maria Júlia Mancim-
Autor(es): dc.creatorMinhaco, Vivian M Tellaroli Rodrigues-
Autor(es): dc.creatorSpolidorio, Denise M Palomari-
Data de aceite: dc.date.accessioned2025-08-21T22:36:17Z-
Data de disponibilização: dc.date.available2025-08-21T22:36:17Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2022-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1590/0103-6440202305133-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/246962-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/246962-
Descrição: dc.descriptionThis study evaluated the antimicrobial capacity of BlueM® mouthwash against the bacterium Streptococcus mutans and its influence on gbpA gene expression as well as its cytotoxic effect on fibroblast cells. BlueM® showed antimicrobial activity, with MIC and MBC values of 0.005% and 0.01%, respectively. The MBIC was 6.25% for S. mutans. CFU count and confocal microscopy revealed significant effect of BlueM® on S. mutans biofilm pre-formed on dentin surfaces. Interestingly, the analysis of gbpA gene expression indicated a decrease in gene expression after 15 min of treatment with BlueM® at a concentration of 25%. Moreover, BlueM® exhibited low levels of cytotoxicity. In conclusion, our results showed the antimicrobial effectiveness of BlueM® against S. mutans, its ability to modulate the expression of the gbpA gene and its low cytotoxicity. This study supports the therapeutic potential of BlueM® as an alternative agent for the control of oral biofilm.-
Descrição: dc.descriptionDepartment of Physiology and Pathology School of Dentistry São Paulo State University(Unesp)-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery School of Dentistry São Paulo State University (Unesp)-
Descrição: dc.descriptionDepartment of Physiology and Pathology School of Dentistry São Paulo State University(Unesp)-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery School of Dentistry São Paulo State University (Unesp)-
Formato: dc.format19-28-
Idioma: dc.languageen-
Relação: dc.relationBrazilian dental journal-
???dc.source???: dc.sourceScopus-
Título: dc.titleEffects of BlueM® against Streptococcus mutans biofilm and its virulence gene expression-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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