Bacterial cellulose membrane incorporated with silver nanoparticles for wound healing in animal model

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversity Centre of Herminio Ometto Foundation-
Autor(es): dc.contributorUniversity of Araraquara (UNIARA)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade do Extremo Sul Catarinense (UNESC)-
Autor(es): dc.creatorMunhoz, Lauriene Luiza S.-
Autor(es): dc.creatorAlves, Miriã Tonus O.-
Autor(es): dc.creatorAlves, Beatriz C.-
Autor(es): dc.creatorNascimento, Maria Gabriela F.S.-
Autor(es): dc.creatorSábio, Rafael M.-
Autor(es): dc.creatorManieri, Karyn F.-
Autor(es): dc.creatorBarud, Hernane S.-
Autor(es): dc.creatorEsquisatto, Marcelo Augusto M.-
Autor(es): dc.creatorAro, Andrea A.-
Autor(es): dc.creatorde Roch Casagrande, Laura-
Autor(es): dc.creatorSilveira, Paulo Cesar Lock-
Autor(es): dc.creatorSantos, Glaucia Maria T.-
Autor(es): dc.creatorAndrade, Thiago A.M.-
Autor(es): dc.creatorCaetano, Guilherme F.-
Data de aceite: dc.date.accessioned2025-08-21T15:24:11Z-
Data de disponibilização: dc.date.available2025-08-21T15:24:11Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-04-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.bbrc.2023.02.058-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/246947-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/246947-
Descrição: dc.descriptionThe bacterial cellulose membrane (CM) is a promising biomaterial due to its easy applicability and moist environment. Moreover, nanoscale silver compounds (AgNO3) are synthesized and incorporated into CMs to provide these biomaterials with antimicrobial activity for wound healing. This study aimed to evaluate the cell viability of CM incorporated with nanoscale silver compounds, determine the minimum inhibitory concentration (MIC) for Escherichia coli and Staphylococcus aureus, and its use on in vivo skin lesions. Wistar rats were divided according to treatment: untreated, CM (cellulose membrane), and AgCM (CM incorporated with silver nanoparticles). The euthanasia was performed on the 2nd, 7th, 14th, and 21st days to assess inflammation (myeloperoxidase-neutrophils, N-acetylglucosaminidase-macrophage, IL-1β, IL-10), oxidative stress (NO-nitric oxide, DCF-H2O2), oxidative damage (carbonyl: membrane's damage; sulfhydryl: membrane's integrity), antioxidants (superoxide dismutase; glutathione), angiogenesis, tissue formation (collagen, TGF-β1, smooth muscle α-actin, small decorin, and biglycan proteoglycans). The use of AgCM did not show toxicity, but antibacterial effect in vitro. Moreover, in vivo, AgCM provided balanced oxidative action, modulated the inflammatory profile due to the reduction of IL-1β level and increase in IL-10 level, in addition to increased angiogenesis and collagen formation. The results suggest the use of silver nanoparticles (AgCM) enhanced the CM properties by providing antibacterial properties, modulation the inflammatory phase, and consequently promotes the healing of skin lesions, which can be used clinically to treat injuries.-
Descrição: dc.descriptionGraduate Program in Biomedical Sciences University Centre of Herminio Ometto Foundation, Araras-
Descrição: dc.descriptionBioPolymer and Biomaterial Laboratory (BioPolMat) University of Araraquara (UNIARA), Araraquara-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences São Paulo State University – UNESP, Araraquara-
Descrição: dc.descriptionLaboratory of Experimental Physiopathology Graduate Program in Science of Health Universidade do Extremo Sul Catarinense (UNESC), Santa Catarina-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences São Paulo State University – UNESP, Araraquara-
Formato: dc.format47-54-
Idioma: dc.languageen-
Relação: dc.relationBiochemical and Biophysical Research Communications-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBacterial cellulose-
Palavras-chave: dc.subjectBiomembrane-
Palavras-chave: dc.subjectInflammation-
Palavras-chave: dc.subjectOxidative stress-
Palavras-chave: dc.subjectSilver nanoparticles-
Palavras-chave: dc.subjectTissue formation-
Título: dc.titleBacterial cellulose membrane incorporated with silver nanoparticles for wound healing in animal model-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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