Potential application for antimicrobial and antileukemic therapy of a flavonoid-rich fraction of Camellia sinensis

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Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorIVAGRO-
Autor(es): dc.creatorde Souza, Mariana C.-
Autor(es): dc.creatorde Souza Mesquita, Leonardo M.-
Autor(es): dc.creatorPena, Fabíola L.-
Autor(es): dc.creatorTamborlin, Leticia-
Autor(es): dc.creatorda Silva, Laise C.-
Autor(es): dc.creatorViganó, Juliane-
Autor(es): dc.creatorAntunes, Adriane E. Costa-
Autor(es): dc.creatorLuchessi, Augusto D.-
Autor(es): dc.creatorDuarte, Marta C. Teixeira-
Autor(es): dc.creatorBarbero, Gerardo F.-
Autor(es): dc.creatorRostagno, Mauricio A.-
Data de aceite: dc.date.accessioned2025-08-21T21:53:27Z-
Data de disponibilização: dc.date.available2025-08-21T21:53:27Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2022-10-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.focha.2022.100042-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/246928-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/246928-
Descrição: dc.descriptionThe antimicrobial and antileukemic effect of a purified fraction of flavonoids from the leaves of Camellia sinensis was evaluated. An extraction yield of 9.77 mg.g-1 total flavonoids was recovered through a pressurized liquid extraction associated with solid-phase extraction. This fraction was tested against pathogenic microorganisms (Staphylococcus, Salmonella, and Enterococcus), considering the minimum inhibitory concentration. In addition, the human monocyte cell line THP-1, derived from a patient with acute monocytic leukemia, was used for the antitumor assay. The results show that the flavonoid-rich fraction obtained by coupling a Pressurized Liquids Extraction in-line with a Solid Phase Extraction (PLE-SPE) has a high antimicrobial effect and resulted in cell cycle blockage G0 / G1, increased DNA fragmentation, and altered leukemic cell morphology. These results suggest that a flavonoid-rich fraction obtained from Camellia sinensis can be applied as potential adjuvants in chemotherapy treatment to mitigate the side effects caused by chemotherapy or even as a supplement to cancer therapy.-
Descrição: dc.descriptionSchool of Applied Sciences University of Campinas (UNICAMP), São Paulo-
Descrição: dc.descriptionInstitute of Biosciences São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionPluridisciplinary Center for Chemical Biological and Agricultural Research University of Campinas (UNICAMP), São Paulo-
Descrição: dc.descriptionDepartment of Analytical Chemistry University of Cadiz IVAGRO, Cadiz-
Descrição: dc.descriptionInstitute of Biosciences São Paulo State University (UNESP), São Paulo-
Idioma: dc.languageen-
Relação: dc.relationFood Chemistry Advances-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCancer therapy-
Palavras-chave: dc.subjectCoupled extraction techniques-
Palavras-chave: dc.subjectFlavonoids-
Palavras-chave: dc.subjectTheaflavin-
Palavras-chave: dc.subjectTHP-1-
Título: dc.titlePotential application for antimicrobial and antileukemic therapy of a flavonoid-rich fraction of Camellia sinensis-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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