Melatonin modulates the Warburg effect and alters the morphology of hepatocellular carcinoma cell line resulting in reduced viability and migratory potential

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Autor(es): dc.contributorUniversidade Estadual de Londrina (UEL)-
Autor(es): dc.contributorCedars-Sinai Medical Center-
Autor(es): dc.contributorCentro de Ciências Biológicas-
Autor(es): dc.contributorUniversidade Estadual de Maringá (UEM)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Estadual do Oeste do Paraná-
Autor(es): dc.creatorCruz, Ellen Mayara Souza-
Autor(es): dc.creatorConcato, Virginia Marcia-
Autor(es): dc.creatorde Morais, Juliana Maria Bitencourt-
Autor(es): dc.creatorSilva, Taylon Felipe-
Autor(es): dc.creatorInoue, Fabricio Seidy Ribeiro-
Autor(es): dc.creatorde Souza Cremer, Milena-
Autor(es): dc.creatorBidóia, Danielle Lazarin-
Autor(es): dc.creatorMachado, Rayanne Regina Beltrame-
Autor(es): dc.creatorde Almeida Chuffa, Luiz Gustavo-
Autor(es): dc.creatorMantovani, Mário Sérgio-
Autor(es): dc.creatorPanis, Carolina-
Autor(es): dc.creatorPavanelli, Wander Rogério-
Autor(es): dc.creatorSeiva, Fábio Rodrigues Ferreira-
Data de aceite: dc.date.accessioned2025-08-21T17:09:34Z-
Data de disponibilização: dc.date.available2025-08-21T17:09:34Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-04-15-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.lfs.2023.121530-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/246921-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/246921-
Descrição: dc.descriptionAims: Hepatocellular Carcinoma (HCC) is a primary neoplasm derived from hepatocytes with low responsiveness and recurrent chemoresistance. Melatonin is an alternative agent that may be helpful in treating HCC. We aimed to study in HuH 7.5 cells whether melatonin treatment exerts antitumor effects and, if so, what cellular responses are induced and involved. Main methods: We evaluated the effects of melatonin on cell cytotoxicity and proliferation, colony formation, morphological and immunohistochemical aspects, and on glucose consumption and lactate release. Key findings: Melatonin reduced cell motility and caused lamellar breakdown, membrane damage, and reduction in microvillus. Immunofluorescence analysis revealed that melatonin reduced TGF and N-cadherin expression, which was further associated with inhibition of epithelial-mesenchymal transition process. In relation to the Warburg-type metabolism, melatonin reduced glucose uptake and lactate production by modulating intracellular lactate dehydrogenase activity. Significance: Our results indicate that melatonin can act upon pyruvate/lactate metabolism, preventing the Warburg effect, which may reflect in the cell architecture. We demonstrated the direct cytotoxic and antiproliferative effect of melatonin on the HuH 7.5 cell line, and suggest that melatonin is a promising candidate to be further tested as an adjuvant to antitumor drugs for HCC treatment.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFinanciadora de Estudos e Projetos-
Descrição: dc.descriptionUniversidade Estadual de Londrina-
Descrição: dc.descriptionLaboratory of Immunoparasitology of Neglected Diseases and Cancer State University of Londrina, PR-
Descrição: dc.descriptionDepartment of Surgery Cedars-Sinai Medical Center-
Descrição: dc.descriptionUniversidade Estadual do Norte do Paraná (UENP) Centro de Ciências Biológicas, PR-
Descrição: dc.descriptionLaboratório de Inovação Tecnológica no Desenvolvimento de Fármacos e Cosméticos Universidade Estadual de Maringá (UEM)-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Paulista State University — UNESP, SP-
Descrição: dc.descriptionLaboratory of Toxicological Genetics State University of Londrina, PR-
Descrição: dc.descriptionUniversidade Estadual do Oeste do Paraná, PR-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Paulista State University — UNESP, SP-
Idioma: dc.languageen-
Relação: dc.relationLife Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAdjuvant therapy-
Palavras-chave: dc.subjectHuH 7.5 cell-
Palavras-chave: dc.subjectLiver cancer-
Palavras-chave: dc.subjectWarburg effect-
Título: dc.titleMelatonin modulates the Warburg effect and alters the morphology of hepatocellular carcinoma cell line resulting in reduced viability and migratory potential-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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