Titanium dioxide nanoparticles affect osteoblast-derived exosome cargos and impair osteogenic differentiation of human mesenchymal stem cells

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorNational Institute of Metrology Quality and Technology-
Autor(es): dc.contributorUniversity Grande Rio-
Autor(es): dc.contributorUniversity of Porto-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorFluminense Federal University-
Autor(es): dc.contributorInternational Iberian Nanotechnology Laboratory - INL-
Autor(es): dc.contributorUniversidade Federal do Rio de Janeiro (UFRJ)-
Autor(es): dc.creatorde Souza, Wanderson-
Autor(es): dc.creatorGemini-Piperni, S.-
Autor(es): dc.creatorGrenho, Liliana-
Autor(es): dc.creatorRocha, Luís A.-
Autor(es): dc.creatorGranjeiro, José M.-
Autor(es): dc.creatorMelo, Sonia A.-
Autor(es): dc.creatorFernandes, Maria H.-
Autor(es): dc.creatorRibeiro, Ana R.-
Data de aceite: dc.date.accessioned2025-08-21T21:57:27Z-
Data de disponibilização: dc.date.available2025-08-21T21:57:27Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-02-08-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1039/d2bm01854c-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/246880-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/246880-
Descrição: dc.descriptionTitanium (Ti) and its alloys are the most widely used metallic biomaterials in total joint replacement; however, increasing evidence supports the degradation of its surface due to corrosion and wear processes releasing debris (ions, and micro and nanoparticles) and contribute to particle-induced osteolysis and implant loosening. Cell-to-cell communication involving several cell types is one of the major biological processes occurring during bone healing and regeneration at the implant-bone interface. In addition to the internal response of cells to the uptake and intracellular localization of wear debris, a red flag is the ability of titanium dioxide nanoparticles (mimicking wear debris) to alter cellular communication with the tissue background, disturbing the balance between osseous tissue integrity and bone regenerative processes. This study aims to understand whether titanium dioxide nanoparticles (TiO2 NPs) alter osteoblast-derived exosome (Exo) biogenesis and whether exosomal protein cargos affect the communication of osteoblasts with human mesenchymal stem/stromal cells (HMSCs). Osteoblasts are derived from mesenchymal stem cells coexisting in the bone microenvironment during development and remodelling. We observed that TiO2 NPs stimulate immature osteoblast- and mature osteoblast-derived Exo secretion that present a distinct proteomic cargo. Functional tests confirmed that Exos derived from both osteoblasts decrease the osteogenic differentiation of HMSCs. These findings are clinically relevant since wear debris alter extracellular communication in the bone periprosthetic niche, contributing to particle-induced osteolysis and consequent prosthetic joint failure.-
Descrição: dc.descriptionMarathon-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionEuropean Regional Development Fund-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ)-
Descrição: dc.descriptionFuel Cell Technologies Program-
Descrição: dc.descriptionFundació Catalana de Trasplantament-
Descrição: dc.descriptionFundação para a Ciência e a Tecnologia-
Descrição: dc.descriptionHorizon 2020 Framework Programme-
Descrição: dc.descriptionMinistério da Ciência e Tecnologia-
Descrição: dc.descriptionMinistério da Ciência, Tecnologia e Inovação-
Descrição: dc.descriptionMinistério da Educação-
Descrição: dc.descriptionMinistério da Educação e Ciência-
Descrição: dc.descriptionMinistério da Saúde-
Descrição: dc.descriptionOkayama Foundation for Science and Technology-
Descrição: dc.descriptionDirectory of Metrology Applied to Life Sciences National Institute of Metrology Quality and Technology-
Descrição: dc.descriptionPostgraduate Program in Biotechnology National Institute of Metrology Quality and Technology-
Descrição: dc.descriptionPostgraduate Program in Translational Biomedicine University Grande Rio-
Descrição: dc.descriptionFaculty of Dental Medicine University of Porto-
Descrição: dc.descriptionPhysics Department Paulista State University-
Descrição: dc.descriptionIBTN/Br - Brazilian Branch of the Institute of Biomaterials Tribocorrosion and Nanomedicine São Paulo State University, Bauru-
Descrição: dc.descriptionDental School Fluminense Federal University-
Descrição: dc.descriptioni3S-Institute for Research and Innovation in Health University of Porto-
Descrição: dc.descriptionLAQV/REQUIMTE University of Porto-
Descrição: dc.descriptionNanoSafety group International Iberian Nanotechnology Laboratory - INL-
Descrição: dc.descriptionLab?n Group Federal University of Rio de Janeiro (UFRJ)-
Descrição: dc.descriptionPhysics Department Paulista State University-
Descrição: dc.descriptionIBTN/Br - Brazilian Branch of the Institute of Biomaterials Tribocorrosion and Nanomedicine São Paulo State University, Bauru-
Formato: dc.format2427-2444-
Idioma: dc.languageen-
Relação: dc.relationBiomaterials Science-
???dc.source???: dc.sourceScopus-
Título: dc.titleTitanium dioxide nanoparticles affect osteoblast-derived exosome cargos and impair osteogenic differentiation of human mesenchymal stem cells-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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