Insights on β-glucan as a prebiotic coadjuvant in the treatment of diabetes mellitus: A review

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorInstitute of Food Science-
Autor(es): dc.contributorUniversity Pitágoras Unopar (UNOPAR)-
Autor(es): dc.creatorSivieri, Katia-
Autor(es): dc.creatorde Oliveira, Sonia Mariza-
Autor(es): dc.creatorMarquez, Audrey de Souza-
Autor(es): dc.creatorPérez-Jiménez, Jara-
Autor(es): dc.creatorDiniz, Susana Nogueira-
Data de aceite: dc.date.accessioned2025-08-21T15:35:13Z-
Data de disponibilização: dc.date.available2025-08-21T15:35:13Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2022-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.fhfh.2022.100056-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/246862-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/246862-
Descrição: dc.descriptionThe prevalence of Diabetes Mellitus and, particularly, type 2 diabetes (T2D) is increasing every year worldwide. Therefore, changed glucose homeostasis is associated with altered gut microbiota and with the development of type 2 diabetes mellitus (T2DM) and related complications. Among other concerns, an important aspect within this issue is the reversion of dysbiosis reported to be present in T2D patients, in which diet plays a key role, and particularly dietary fiber has shown a promising position. β-glucans are heterogeneous non-starch polysaccharides, constituted by D-glucose monomers linked through different β-glycosidic bonds, and changes in their structure or molecular weight affect the expressed biological properties. They appear in certain cereals, yeasts, or mushrooms and are widely known by their hypocholesterolemia effect. This study explored the current knowledge on the potential of β-glucans to modulate glucose homeostasis due to their prebiotic action, by performing a bibliometric analysis using the VOSviewer software and a narrative review. The bibliometric analysis showed that, despite the high number of references dealing with β-glucan and diabetes, there are few articles on glucans, diabetes, and intestinal dysbiosis. The detailed study on preclinical studies and clinical trials conducted during the last decade showed an improvement in glucose homeostasis due to β-glucan supplementation, studies on biochemical markers, and gut microbiota, and β-glucan are scarce. Nevertheless, existing data showed, both in animals and humans, a tendency towards an increase in beneficial bacteria and in the production of short-chain fat acids (SCFAs), particularly butyric acid. These aspects should be confirmed in the years to come to establish clear recommendations for β-glucan as a prebiotic coadjutant in the management of Diabetes Mellitus.-
Descrição: dc.descriptionBiotechnology and Health Innovation Anhanguera University of São Paulo-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences São Paulo State University, Araraquara-
Descrição: dc.descriptionAnhanguera University of São Paulo-
Descrição: dc.descriptionTechnology and Nutrition Spanish Research Council (ICTAN-CSIC) Institute of Food Science-
Descrição: dc.descriptionCenter of Research in Health Sciences University Pitágoras Unopar (UNOPAR)-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences São Paulo State University, Araraquara-
Idioma: dc.languageen-
Relação: dc.relationFood Hydrocolloids for Health-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBeta-glucan-
Palavras-chave: dc.subjectGlycemic control-
Palavras-chave: dc.subjectMicrobiota dysbiosis-
Palavras-chave: dc.subjectMicrobiota modulation-
Palavras-chave: dc.subjectShort-chain fat acids-
Título: dc.titleInsights on β-glucan as a prebiotic coadjuvant in the treatment of diabetes mellitus: A review-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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