Enhancing chemical and biological diversity by co-cultivation

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorSelegato, Denise M.-
Autor(es): dc.creatorCastro-Gamboa, Ian-
Data de aceite: dc.date.accessioned2025-08-21T23:22:15Z-
Data de disponibilização: dc.date.available2025-08-21T23:22:15Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-01-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3389/fmicb.2023.1117559-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/246855-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/246855-
Descrição: dc.descriptionIn natural product research, microbial metabolites have tremendous potential to provide new therapeutic agents since extremely diverse chemical structures can be found in the nearly infinite microbial population. Conventionally, these specialized metabolites are screened by single-strain cultures. However, owing to the lack of biotic and abiotic interactions in monocultures, the growth conditions are significantly different from those encountered in a natural environment and result in less diversity and the frequent re-isolation of known compounds. In the last decade, several methods have been developed to eventually understand the physiological conditions under which cryptic microbial genes are activated in an attempt to stimulate their biosynthesis and elicit the production of hitherto unexpressed chemical diversity. Among those, co-cultivation is one of the most efficient ways to induce silenced pathways, mimicking the competitive microbial environment for the production and holistic regulation of metabolites, and has become a golden methodology for metabolome expansion. It does not require previous knowledge of the signaling mechanism and genome nor any special equipment for cultivation and data interpretation. Several reviews have shown the potential of co-cultivation to produce new biologically active leads. However, only a few studies have detailed experimental, analytical, and microbiological strategies for efficiently inducing bioactive molecules by co-culture. Therefore, we reviewed studies applying co-culture to induce secondary metabolite pathways to provide insights into experimental variables compatible with high-throughput analytical procedures. Mixed-fermentation publications from 1978 to 2022 were assessed regarding types of co-culture set-ups, metabolic induction, and interaction effects.-
Descrição: dc.descriptionNucleus of Bioassays Biosynthesis and Ecophysiology of natural products (NuBBE) Institute of Chemistry São Paulo State University (UNESP)-
Descrição: dc.descriptionNucleus of Bioassays Biosynthesis and Ecophysiology of natural products (NuBBE) Institute of Chemistry São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationFrontiers in Microbiology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectactivation of Biosynthetic Gene Clusters (BCGs)-
Palavras-chave: dc.subjectenhanced chemodiversity-
Palavras-chave: dc.subjectmicrobial co-culture-
Palavras-chave: dc.subjectmicrobial interaction-
Palavras-chave: dc.subjectuntargeted metabolite regulation-
Título: dc.titleEnhancing chemical and biological diversity by co-cultivation-
Tipo de arquivo: dc.typevídeo-
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